1wf7: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1wf7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WF7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1wf7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WF7 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN 1110001A05 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN 1110001A05 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1wf7 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wf7 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1wf7 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wf7 TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PDLI5_MOUSE PDLI5_MOUSE]] May play an important role in the heart development by scaffolding PKC to the Z-disk region. Isoform 2 and isoform 3 may negatively modulate the scaffolding activity of isoform 1. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Hayashi, F | [[Category: Hayashi, F]] | ||
[[Category: Kigawa, T | [[Category: Kigawa, T]] | ||
[[Category: Qin, X | [[Category: Qin, X]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Tochio, N | [[Category: Tochio, N]] | ||
[[Category: Yokoyama, S | [[Category: Yokoyama, S]] | ||
[[Category: Enigma homologue protein]] | [[Category: Enigma homologue protein]] | ||
[[Category: Pdz domain]] | [[Category: Pdz domain]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
Revision as of 17:29, 25 December 2014
Solution structure of the PDZ domain of Enigma homologue proteinSolution structure of the PDZ domain of Enigma homologue protein
Structural highlights
Function[PDLI5_MOUSE] May play an important role in the heart development by scaffolding PKC to the Z-disk region. Isoform 2 and isoform 3 may negatively modulate the scaffolding activity of isoform 1. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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