2ck5: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ck5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ck5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ck5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ck5 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ck5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ck5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ck5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ck5 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KAX37_ORTSC KAX37_ORTSC]] Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6nM), Kv1.2/KCNA2 (IC(50)=5.4nM), Kv1.3/KCNA3 (IC(50)=0.014nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225nM). At high concentration (2 mM), is also active on Kv1.6/KCNA6 and Shaker IR.[REFERENCE:1]<ref>PMID:15588251</ref> 


==See Also==
==See Also==
*[[Potassium channel toxin|Potassium channel toxin]]
*[[Potassium channel toxin|Potassium channel toxin]]
== References ==
<references/>
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__TOC__
</StructureSection>
</StructureSection>

Revision as of 09:39, 25 December 2014

SOLUTION STRUCTURE OF DELTA 1-7 AOSK1SOLUTION STRUCTURE OF DELTA 1-7 AOSK1

Structural highlights

2ck5 is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[KAX37_ORTSC] Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6nM), Kv1.2/KCNA2 (IC(50)=5.4nM), Kv1.3/KCNA3 (IC(50)=0.014nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225nM). At high concentration (2 mM), is also active on Kv1.6/KCNA6 and Shaker IR.[REFERENCE:1][1]

See Also

References

  1. ↑ Mouhat S, Visan V, Ananthakrishnan S, Wulff H, Andreotti N, Grissmer S, Darbon H, De Waard M, Sabatier JM. K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 1;385(Pt 1):95-104. PMID:15588251 doi:http://dx.doi.org/BJ20041379
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