2ck5

Solution structure of Delta 1-7 aOSK1Solution structure of Delta 1-7 aOSK1

Structural highlights

2ck5 is a 1 chain structure with sequence from Orthochirus scrobiculosus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR, 20 models
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KAX37_ORTSC Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6nM), Kv1.2/KCNA2 (IC(50)=5.4nM), Kv1.3/KCNA3 (IC(50)=0.014nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225nM). At high concentration (2 mM), is also active on Kv1.6/KCNA6 and Shaker IR.[REFERENCE:1]^[1]

References

↑ Mouhat S, Visan V, Ananthakrishnan S, Wulff H, Andreotti N, Grissmer S, Darbon H, De Waard M, Sabatier JM. K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 1;385(Pt 1):95-104. PMID:15588251 doi:http://dx.doi.org/BJ20041379

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OCA

[1] Mouhat S, Visan V, Ananthakrishnan S, Wulff H, Andreotti N, Grissmer S, Darbon H, De Waard M, Sabatier JM. K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 1;385(Pt 1):95-104. PMID:15588251 doi:http://dx.doi.org/BJ20041379

[1]

2ck5

Solution structure of Delta 1-7 aOSK1Solution structure of Delta 1-7 aOSK1

Structural highlights

Function

See Also

References

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2ck5

Solution structure of Delta 1-7 aOSK1Solution structure of Delta 1-7 aOSK1

Structural highlights

Function

See Also

References

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