3afq: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3afq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AFQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AFQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[3afq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AFQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AFQ FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3afp|3afp]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3afp|3afp]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ssb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1769 Mycobacterium leprae])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ssb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1769 Mycobacterium leprae])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3afq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3afq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3afq RCSB], [http://www.ebi.ac.uk/pdbsum/3afq PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3afq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3afq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3afq RCSB], [http://www.ebi.ac.uk/pdbsum/3afq PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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X-ray and molecular-dynamics studies on Mycobacterium leprae single-stranded DNA-binding protein and comparison with other eubacterial SSB structures.,Kaushal PS, Singh P, Sharma A, Muniyappa K, Vijayan M Acta Crystallogr D Biol Crystallogr. 2010 Oct;66(Pt 10):1048-58. Epub 2010 Sep, 18. PMID:20944238<ref>PMID:20944238</ref> | X-ray and molecular-dynamics studies on Mycobacterium leprae single-stranded DNA-binding protein and comparison with other eubacterial SSB structures.,Kaushal PS, Singh P, Sharma A, Muniyappa K, Vijayan M Acta Crystallogr D Biol Crystallogr. 2010 Oct;66(Pt 10):1048-58. Epub 2010 Sep, 18. PMID:20944238<ref>PMID:20944238</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
==See Also== | |||
*[[Single-stranded DNA-binding protein|Single-stranded DNA-binding protein]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mycobacterium leprae]] | [[Category: Mycobacterium leprae]] | ||
[[Category: Kaushal, P S | [[Category: Kaushal, P S]] | ||
[[Category: Muniyappa, K | [[Category: Muniyappa, K]] | ||
[[Category: Sharma, A | [[Category: Sharma, A]] | ||
[[Category: Singh, P | [[Category: Singh, P]] | ||
[[Category: Vijayan, M | [[Category: Vijayan, M]] | ||
[[Category: Changes on oligomerisation]] | [[Category: Changes on oligomerisation]] | ||
[[Category: Dna binding protein]] | [[Category: Dna binding protein]] | ||
Revision as of 03:55, 25 December 2014
Crystal structure of the single-stranded DNA binding protein from Mycobacterium leprae (Form II)Crystal structure of the single-stranded DNA binding protein from Mycobacterium leprae (Form II)
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe crystal structures of two forms of Mycobacterium leprae single-stranded DNA-binding protein (SSB) have been determined at 2.05 and 2.8 A resolution. Comparison of these structures with the structures of other eubacterial SSBs indicates considerable variation in their quaternary association, although the DNA-binding domains in all of them exhibit the same OB-fold. This variation has no linear correlation with sequence variation, but could be related to variation in protein stability. Molecular-dynamics simulations have been carried out on tetrameric molecules derived from the two forms and the prototype Escherichia coli SSB and the individual subunits of both proteins. Together, the X-ray studies and molecular-dynamics simulations yield information on the relatively rigid and flexible regions of the molecule and on the effect of oligomerization on flexibility. The simulations provide insight into the changes in subunit structure on oligomerization. They also provide insight into the stability and time evolution of the hydrogen bonds/water bridges that connect the two pairs of monomers in the tetramer. X-ray and molecular-dynamics studies on Mycobacterium leprae single-stranded DNA-binding protein and comparison with other eubacterial SSB structures.,Kaushal PS, Singh P, Sharma A, Muniyappa K, Vijayan M Acta Crystallogr D Biol Crystallogr. 2010 Oct;66(Pt 10):1048-58. Epub 2010 Sep, 18. PMID:20944238[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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