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==Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with Indole Aza-SAM== | |||
<StructureSection load='4gon' size='340' side='right' caption='[[4gon]], [[Resolution|resolution]] 2.72Å' scene=''> | |||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4gon]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GON FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0Y1:5-{[(3S)-3-AMINO-3-CARBOXYPROPYL][2-(1H-INDOL-3-YL)ETHYL]AMINO}-5-DEOXYADENOSINE'>0Y1</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gbe|4gbe]], [[4gol|4gol]], [[4gom|4gom]], [[4goo|4goo]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b3387, dam, JW3350 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Site-specific_DNA-methyltransferase_(adenine-specific) Site-specific DNA-methyltransferase (adenine-specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.72 2.1.1.72] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gon OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gon RCSB], [http://www.ebi.ac.uk/pdbsum/4gon PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/DMA_ECOLI DMA_ECOLI]] Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication. | [[http://www.uniprot.org/uniprot/DMA_ECOLI DMA_ECOLI]] Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication. | ||
__TOC__ | |||
</StructureSection> | |||
[[ | [[Category: Ecoli]] | ||
[[Category: Harmer, J E | [[Category: Harmer, J E]] | ||
[[Category: Roach, P L | [[Category: Roach, P L]] | ||
[[Category: Methylation]] | [[Category: Methylation]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 16:55, 24 December 2014
Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with Indole Aza-SAMCrystal Structure of E. coli DNA Adenine Methyltransferase in Complex with Indole Aza-SAM
Structural highlights
Function[DMA_ECOLI] Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication. |
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