Sandbox Reserved 820: Difference between revisions
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<StructureSection load='2vaf' size='450' side='right'caption='Crystal Structure of Human Cardiac Calsequestrin, (PDB code [[2vaf]]) ' scene='56/568018/General_structure/4' > | <StructureSection load='2vaf' size='450' side='right'caption='Crystal Structure of Human Cardiac Calsequestrin, (PDB code [[2vaf]]) ' scene='56/568018/General_structure/4' > | ||
'''Calsequestrin-2''' (or '''CASQ2''') is the soluble Ca<sup>2+</sup> binding protein in the sarcoplasmic reticulum lumen of the cardiac muscle cells. CASQ2 could be either in a monomeric, homodimeric, or homooligomeric chain form depending on its bounds with Ca<sup>2+</sup>. Mutations of CASQ2 are involved in cardiac diseases such as Catecholaminergic Polymorphic Ventricular Tachycardia.<ref name="Cerrone">PMID:19879546</ref> | '''Calsequestrin-2''' (or '''CASQ2''') is the soluble Ca<sup>2+</sup> binding protein in the sarcoplasmic reticulum lumen of the cardiac muscle cells. CASQ2 could be either in a monomeric, homodimeric, or homooligomeric chain form depending on its bounds with Ca<sup>2+</sup>. Mutations of CASQ2 are involved in cardiac diseases such as Catecholaminergic Polymorphic Ventricular Tachycardia.<ref name="Cerrone">PMID:19879546</ref> | ||
[[Image: | [[Image:.gif|350px|left|thumb|Calsequestrin in the calcium cycle of myocyte contraction]] | ||
{{clear}} | {{clear}} | ||
== Biological role == | == Biological role == | ||