Exotoxin: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
</StructureSection>


==3D structures of exotoxin==
==3D structures of exotoxin==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


===''Pseudomonas aeruginosa'' exotoxin===
*''Pseudomonas aeruginosa'' exotoxin


[[1ikq]] – PaET A <br />
**[[1ikq]] – PaET A <br />
[[1ikp]] – PaET A (mutant) <br />
**[[1ikp]] – PaET A (mutant) <br />
[[1dma]] – PaET A catalytic domain + nicotinamide + AMP <br />
**[[1dma]] – PaET A catalytic domain + nicotinamide + AMP <br />
[[1aer]] – PaET A catalytic domain + NAD analog + AMP <br />
**[[1aer]] – PaET A catalytic domain + NAD analog + AMP <br />
[[1xk9]] – PaET A catalytic domain + inhibitor <br />
**[[1xk9]] – PaET A catalytic domain + inhibitor <br />
[[1zm2]] – PaET A catalytic domain + diphthamide + adenosine diphosphoribose + EF-2 <br />
**[[1zm2]] – PaET A catalytic domain + diphthamide + adenosine diphosphoribose + EF-2 <br />
[[1zm3]] – PaET A catalytic domain + diphthamide + EF-2 <br />
**[[1zm3]] – PaET A catalytic domain + diphthamide + EF-2 <br />
[[3b78]], [[2zit]] – PaET A catalytic domain + diphthamide + NAD + EF-2 <br />
**[[3b78]], [[2zit]] – PaET A catalytic domain + diphthamide + NAD + EF-2 <br />
[[3b82]], [[3b8h]] – PaET A catalytic domain (mutant) + diphthamide + NAD + EF-2 <br />
**[[3b82]], [[3b8h]] – PaET A catalytic domain (mutant) + diphthamide + NAD + EF-2 <br />
[[1zm4]] – PaET A catalytic domain + diphthamide + NAD analog + EF-2 <br />
**[[1zm4]] – PaET A catalytic domain + diphthamide + NAD analog + EF-2 <br />
[[1zm9]] – PaET A catalytic domain + diphthamide + inhibitor + EF-2 <br />
**[[1zm9]] – PaET A catalytic domain + diphthamide + inhibitor + EF-2 <br />


===''Vibrio cholerae'' exotoxin===
*''Vibrio cholerae'' exotoxin


[[2q5t]] – VcET <br />
**[[2q5t]] – VcET <br />
[[2q6m]], [[3ess]], [[3ki0]], [[3ki1]], [[3ki2]], [[3ki3]], [[3ki4]], [[3ki5]], [[3ki6]], [[3ki7]], [[3ny6]] – VcET catalytic domain + inhibitor <br />
**[[2q6m]], [[3ess]], [[3ki0]], [[3ki1]], [[3ki2]], [[3ki3]], [[3ki4]], [[3ki5]], [[3ki6]], [[3ki7]], [[3ny6]] – VcET catalytic domain + inhibitor <br />
[[3q9o]] – VcET + NAD <br />
**[[3q9o]] – VcET + NAD <br />


===''Streptococcus pyogenes'' exotoxin===
*''Streptococcus pyogenes'' exotoxin


[[1b1z]], [[1fnu]], [[1fnv]], [[1fnw]] – SpET A1 <br />
**[[1b1z]], [[1fnu]], [[1fnv]], [[1fnw]] – SpET A1 <br />
[[1dki]] – SpET B<br />
**[[1dki]] – SpET B<br />
[[2jtc]] – SpET B (mutant) - NMR<br />
**[[2jtc]] – SpET B (mutant) - NMR<br />
[[1an8]] – SpET C<br />
**[[1an8]] – SpET C<br />
[[1et9]] – SpET H<br />
**[[1et9]] – SpET H<br />
[[1ty0]] – SpET J<br />
**[[1ty0]] – SpET J<br />
[[1ha5]], [[1uup]] – SpET A1 + Zn<br />
**[[1ha5]], [[1uup]] – SpET A1 + Zn<br />
[[1l0x]] – SpET A1 (mutant) + T cell receptor β chain<br />
**[[1l0x]] – SpET A1 (mutant) + T cell receptor β chain<br />
[[1pvj]] – SpET B + inhibitor <br />
**[[1pvj]] – SpET B + inhibitor <br />
[[2uzj]] – SpET B + guanidine derivative <br />
**[[2uzj]] – SpET B + guanidine derivative <br />
[[1eu4]] – SpET H + Zn<br />
**[[1eu4]] – SpET H + Zn<br />
[[1ty2]] – SpET J + Zn<br />
**[[1ty2]] – SpET J + Zn<br />
[[1ktk]] – SpET C (mutant) + T cell receptor β chain<br />
**[[1ktk]] – SpET C (mutant) + T cell receptor β chain<br />
[[1l0y]] – SpET A1 (mutant) + T cell receptor β chain + Zn<br />
**[[1l0y]] – SpET A1 (mutant) + T cell receptor β chain + Zn<br />
[[1hqr]] – SpRT C + antibody + myelin basic protein<br />
**[[1hqr]] – SpRT C + antibody + myelin basic protein<br />


===''Staphylococcus aureus'' exotoxin===
*''Staphylococcus aureus'' exotoxin


[[1v1o]], [[1v1p]] – SaET 1 <br />
**[[1v1o]], [[1v1p]] – SaET 1 <br />
[[2r61]], [[2z8l]] – SaET 3<br />
**[[2r61]], [[2z8l]] – SaET 3<br />
[[3o13]] – SaET 15<br />
**[[3o13]] – SaET 15<br />
[[3kls]] – SaET 1 (mutant) + complement C5<br />
**[[3kls]] – SaET 1 (mutant) + complement C5<br />
 
===''Corynebacterium diphtheriae'' exotoxin===
 
See [[Diphtheria toxin]]


*''Corynebacterium diphtheriae'' exotoxin See [[Diphtheria toxin]]


}}





Revision as of 16:04, 24 November 2014


Function

Exotoxins (ET) are toxins which are secreted by bacteria.

Disease

Relevance

Structural highlights

Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code 3q9o).

Drag the structure with the mouse to rotate

3D structures of exotoxin3D structures of exotoxin

Updated on 24-November-2014



ReferencesReferences

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky