DNA methyltransferase: Difference between revisions

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


===Methylguanine DNMT===
*Methylguanine DNMT


[[1sfe]] – O6-methylguanine DNMT C terminal – ''Escherichia coli''
**[[1sfe]] – O6-methylguanine DNMT C terminal – ''Escherichia coli''


[[1qnt]], [[1eh6]], [[3llr]] - hO6-methylguanine DNMT – human
**[[1qnt]], [[1eh6]], [[3llr]] - hO6-methylguanine DNMT – human


[[1t38]] - hO6-methylguanine DNMT (mutant) + DNA
**[[1t38]] - hO6-methylguanine DNMT (mutant) + DNA


[[1t39]], [[1yfh]] - hO6-methylguanine DNMT + DNA
**[[1t39]], [[1yfh]] - hO6-methylguanine DNMT + DNA


[[1eh7]] - hO6-methylguanine DNMT methylated
**[[1eh7]] - hO6-methylguanine DNMT methylated


[[1eh8]] - hO6-methylguanine DNMT benzylated<br />
**[[1eh8]] - hO6-methylguanine DNMT benzylated<br />
[[1mgt]]- O6-methylguanine DNMT – ''Thermococcus kodakarensis''<br />
**[[1mgt]] - O6-methylguanine DNMT – ''Thermococcus kodakarensis''<br />
[[1wrj]] - O6-methylguanine DNMT  - ''Sulfolobus tokodaii''
**[[1wrj]] - O6-methylguanine DNMT  - ''Sulfolobus tokodaii''


[[2g7h]] - O6-methylguanine DNMT – ''Methanocaldococcus jannaschii''
**[[2g7h]] - O6-methylguanine DNMT – ''Methanocaldococcus jannaschii''


[[2kif]], [[2kim]] - O6-methylguanine DNMT – ''Vibrio parahaemolyticus'' - NMR<br />
**[[2kif]], [[2kim]] - O6-methylguanine DNMT – ''Vibrio parahaemolyticus'' - NMR<br />
[[4bhb]], [[4bhc]] - O6-methylguanine DNMT (mutant) – ''Mycobacterium tuberculosis''<br />
**[[4bhb]], [[4bhc]] - O6-methylguanine DNMT (mutant) – ''Mycobacterium tuberculosis''<br />


===Methylcytosine DNMT===
*Methylcytosine DNMT


[[2qrv]] - h-cytosine DNMT
**[[2qrv]] - h-cytosine DNMT


[[3epz]] - h-cytosine DNMT replecation foci-targeting sequence
**[[3epz]] - h-cytosine DNMT replecation foci-targeting sequence


[[3flg]] - h-cytosine DNMT ADD domain
**[[3flg]] - h-cytosine DNMT ADD domain


[[3a1a]] - h-cytosine DNMT PWWP domain
**[[3a1a]] - h-cytosine DNMT PWWP domain


[[1g55]] - h-cytosine DNMT2 (mutant)<br />
**[[1g55]] - h-cytosine DNMT2 (mutant)<br />
[[3qkj]] - h-cytosine DNMT 3β<br />
**[[3qkj]] - h-cytosine DNMT 3β<br />
[[3av4]], [[1khc]] - m-cytosine DNMT – mouse
**[[3av4]], [[1khc]] - m-cytosine DNMT – mouse


[[2uyc]], [[2uyh]], [[2uz4]] - Hh-cytosine DNMT (mutant) + DNA + SAH
**[[2uyc]], [[2uyh]], [[2uz4]] - Hh-cytosine DNMT (mutant) + DNA + SAH


[[3a1b]] - h-cytosine DNMT ADD domain + histone H3
**[[3a1b]] - h-cytosine DNMT ADD domain + histone H3


[[3pt6]], [[3pt9]], [[4da4]] – m-cytosine DNMT + DNA
**[[3pt6]], [[3pt9]], [[4da4]] – m-cytosine DNMT + DNA
   
   
[[3av5]] - m-cytosine DNMT + SAH
**[[3av5]] - m-cytosine DNMT + SAH


[[3av6]] - m-cytosine DNMT + SAM
**[[3av6]] - m-cytosine DNMT + SAM


[[3swr]] - h-cytosine DNMT + sinefungin
**[[3swr]] - h-cytosine DNMT + sinefungin


[[1boo]] - cytosine DNMT (mutant) – ''Proteus vulgaris''<br />
**[[1boo]] - cytosine DNMT (mutant) – ''Proteus vulgaris''<br />
[[3qv2]] - cytosine DNMT + SAH – ''Entamoeba histolytica''<br />
**[[3qv2]] - cytosine DNMT + SAH – ''Entamoeba histolytica''<br />
[[2uyc]], [[2uyh]], [[2uz4]], [[1fjx]] – Hh-cytosine DNMT (mutant) + DNA + SAH - ''Haemophilus haemolyticus''<br />
**[[2uyc]], [[2uyh]], [[2uz4]], [[1fjx]] – Hh-cytosine DNMT (mutant) + DNA + SAH - ''Haemophilus haemolyticus''<br />
[[2c7o]], [[2c7p]], [[2c7q]], [[2c7r]], [[3pta]] – Hh-cytosine DNMT + DNA + S-adenonosyl cysteine<br />
**[[2c7o]], [[2c7p]], [[2c7q]], [[2c7r]], [[3pta]] – Hh-cytosine DNMT + DNA + S-adenonosyl cysteine<br />
[[1hmy]] – Hh-cytosine Haeiii DNMT + SAM
**[[1hmy]] – Hh-cytosine Haeiii DNMT + SAM


**[[1m0e]] - Hh-cytosine DNMT (mutant) + DNA + inhibitor


[[1m0e]] - Hh-cytosine DNMT (mutant) + DNA + inhibitor
**[[2i9k]] - Hh-cytosine DNMT (mutant) + DNA


[[2i9k]] - Hh-cytosine DNMT (mutant) + DNA
**[[2hr1]] - Hh-cytosine DNMT + DNA + ADOHCY


[[2hr1]] - Hh-cytosine DNMT + DNA + ADOHCY
**[[2z6q]], [[2z6u]], [[2zcj]] - Hh-cytosine DNMT (mutant) + DNA + ADOHCY


[[2z6q]], [[2z6u]], [[2zcj]] - Hh-cytosine DNMT (mutant) + DNA + ADOHCY
**[[1svu]] - Hh-cytosine DNMT (mutant)<br />
**[[4fsx]] – c-cytosine DNMT + SAH – corn<br />
**[[4ft2]], [[4ft4]] – c-cytosine DNMT + histone H3 peptide<br />
**[[4h0n]] - cytosine DNMT (mutant) – ''Spodoptera frugiperda''


[[1svu]] - Hh-cytosine DNMT (mutant)<br />
*Methyladenine DNMT
[[4fsx]] – c-cytosine DNMT + SAH – corn<br />
[[4ft2]], [[4ft4]] – c-cytosine DNMT + histone H3 peptide<br />
[[4h0n]] - cytosine DNMT (mutant) – ''Spodoptera frugiperda''


===Methyladenine DNMT===
**[[1nw5]] – RsN6-adenine DNMT + SAM – ''Rhodobacter sphaeroides''


[[1nw5]] – RsN6-adenine DNMT + SAM – ''Rhodobacter sphaeroides''
**[[1nw6]] - RsN6-adenine DNMT + sinefungin<br />
 
**[[1nw7]] - RsN6-adenine DNMT + SAH<br />
[[1nw6]] - RsN6-adenine DNMT + sinefungin<br />
**[[1nw8]] - RsN6-adenine DNMT (mutant)
[[1nw7]] - RsN6-adenine DNMT + SAH<br />
[[1nw8]] - RsN6-adenine DNMT (mutant)
 
[[2ibs]], [[2ibt]], [[2ih2]], [[2ih4]], [[2ih5]], [[2np6]], [[2np7]], [[1g38]] - Ta-adenine DNMT Taqi + DNA + cofactor analog – ''Thermus aquaticus''<br />
[[1aqi]] – Ta-adenine DNMT Taqi + SAH<br />
[[1aqj]] – Ta-adenine DNMT Taqi + sinefugin<br />
[[2adm]] - Ta-adenine DNMT Taqi + SAM<br />
[[1g60]] - adenine DNMT + SAM – ''Moraxella bovis''


**[[2ibs]], [[2ibt]], [[2ih2]], [[2ih4]], [[2ih5]], [[2np6]], [[2np7]], [[1g38]] - Ta-adenine DNMT Taqi + DNA + cofactor analog – ''Thermus aquaticus''<br />
**[[1aqi]] – Ta-adenine DNMT Taqi + SAH<br />
**[[1aqj]] – Ta-adenine DNMT Taqi + sinefugin<br />
**[[2adm]] - Ta-adenine DNMT Taqi + SAM<br />
**[[1g60]] - adenine DNMT + SAM – ''Moraxella bovis''
}}




Revision as of 12:11, 24 November 2014

Template:STRUCTURE 1qnt

DNA methyltransferase (DNMT) catalyzes the transfer of methyl group to DNA. DNMT uses S-adenosyl methionine (SAM) as the methyl donor. The SAM analog S-adenosyl homocysteine (SAH) is a powerful inhibitor of DNMT.

3D Structures of DNA methyltransferase3D Structures of DNA methyltransferase

Updated on 24-November-2014

    • 3av5 - m-cytosine DNMT + SAH
    • 3av6 - m-cytosine DNMT + SAM
    • 3swr - h-cytosine DNMT + sinefungin
    • 1boo - cytosine DNMT (mutant) – Proteus vulgaris
    • 3qv2 - cytosine DNMT + SAH – Entamoeba histolytica
    • 2uyc, 2uyh, 2uz4, 1fjx – Hh-cytosine DNMT (mutant) + DNA + SAH - Haemophilus haemolyticus
    • 2c7o, 2c7p, 2c7q, 2c7r, 3pta – Hh-cytosine DNMT + DNA + S-adenonosyl cysteine
    • 1hmy – Hh-cytosine Haeiii DNMT + SAM
    • 1m0e - Hh-cytosine DNMT (mutant) + DNA + inhibitor
    • 2i9k - Hh-cytosine DNMT (mutant) + DNA
    • 2hr1 - Hh-cytosine DNMT + DNA + ADOHCY
    • 2z6q, 2z6u, 2zcj - Hh-cytosine DNMT (mutant) + DNA + ADOHCY
    • 1svu - Hh-cytosine DNMT (mutant)
    • 4fsx – c-cytosine DNMT + SAH – corn
    • 4ft2, 4ft4 – c-cytosine DNMT + histone H3 peptide
    • 4h0n - cytosine DNMT (mutant) – Spodoptera frugiperda
  • Methyladenine DNMT
    • 1nw5 – RsN6-adenine DNMT + SAM – Rhodobacter sphaeroides
    • 1nw6 - RsN6-adenine DNMT + sinefungin
    • 1nw7 - RsN6-adenine DNMT + SAH
    • 1nw8 - RsN6-adenine DNMT (mutant)
    • 2ibs, 2ibt, 2ih2, 2ih4, 2ih5, 2np6, 2np7, 1g38 - Ta-adenine DNMT Taqi + DNA + cofactor analog – Thermus aquaticus
    • 1aqi – Ta-adenine DNMT Taqi + SAH
    • 1aqj – Ta-adenine DNMT Taqi + sinefugin
    • 2adm - Ta-adenine DNMT Taqi + SAM
    • 1g60 - adenine DNMT + SAM – Moraxella bovis

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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