Sandbox CYP450: Difference between revisions
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== The Heme Group is Vital for the Enzyme's Action == | == The Heme Group is Vital for the Enzyme's Action == | ||
Lets look at the heme now. Click the following link to hide the rest of the protein and < | Lets look at the heme now. Click the following link to hide the rest of the protein and <scene name='Hemoglobin/Deoxyheme/8'>view only the heme ring system</scene>. Carbon atoms are shown in grey, Nitrogen atoms are blue, Oxygen is red, and the central Iron atom is orange. The Iron atom is a vital center for oxidation of substrates (drugs or other xenobiotics). Rotate and re-size as necessary to shown that the heme is highly planar. Do you recognize the 4 pyrrole rings within the heme? | ||
Examine the Iron atom in the heme. It is capable of forming 6 bonds. Four of those are with the 4 pyrrole rings that make up the porphyrin ring system. The fifth and sixth bonds are made to atoms above and below the plane of heme ring. The fifth is made to a cysteine residue present on the protein. The final bond is made to an Oxygen molecule (not shown). This Oxygen is activated for oxidation of substrates, and would appear directly between the substrate and the Iron atom. | Examine the Iron atom in the heme. It is capable of forming 6 bonds. Four of those are with the 4 pyrrole rings that make up the porphyrin ring system. The fifth and sixth bonds are made to atoms above and below the plane of heme ring. The fifth is made to a cysteine residue present on the protein. The final bond is made to an Oxygen molecule (not shown). This Oxygen is activated for oxidation of substrates, and would appear directly between the substrate and the Iron atom. | ||