1hrp: Difference between revisions

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CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN

OverviewOverview

The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. This same folding motif is found in some protein growth factors. The heterodimer is stabilized by a segment of the beta-subunit which wraps around the alpha-subunit and is covalently linked like a seat belt by the disulphide Cys 26-Cys 110. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones.

About this StructureAbout this Structure

1HRP is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of human chorionic gonadotropin., Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW, Nature. 1994 Jun 9;369(6480):455-61. PMID:8202136

Page seeded by OCA on Thu Mar 20 11:40:47 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1hrp.gif|left|200px]]<br /><applet load="1hrp" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1hrp.gif|left|200px]]
-caption="1hrp, resolution 3.0&Aring;" />
-'''CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN'''<br />
+ {{Structure
+|PDB= 1hrp |SIZE=350|CAPTION= <scene name='initialview01'>1hrp</scene>, resolution 3.0&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-HRP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRP OCA].
+HRP is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRP OCA].
 ==Reference==
-Crystal structure of human chorionic gonadotropin., Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW, Nature. 1994 Jun 9;369(6480):455-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8202136 8202136]
+Crystal structure of human chorionic gonadotropin., Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW, Nature. 1994 Jun 9;369(6480):455-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8202136 8202136]
 [[Category: Protein complex]]
 [[Category: Harris, D C.]]
@@ Line 18: / Line 27: @@
 [[Category: hormone]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:04:18 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:40:47 2008''