Talin: Difference between revisions

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{{STRUCTURE_2x0c|  PDB=2x0c  | SIZE=400| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }}
{{STRUCTURE_2x0c|  PDB=2x0c  | SIZE=400| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }}


[[Talin]] is involved in cell-cell contacts.  It links integrins to actin.  It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3.  The F3 subdomains interacts with integrin.  Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3. The images at the left and at the right correspond to one representative Talin, ''i.e.'' the crystal structure of mouse Talin rod ([[2x0c]]).
[[Talin]] is involved in cell-cell contacts.  It links integrins to actin.  It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3.  The F3 subdomains interacts with integrin.  Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3.  


== 3D Structures of Talin ==
== 3D Structures of Talin ==

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Alexander Berchansky, Michal Harel, Joel L. Sussman