Glyoxalase: Difference between revisions
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{{STRUCTURE_1qin| PDB=1qin | SIZE=400| SCENE= |right|CAPTION=Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion, [[1qin]] }} | {{STRUCTURE_1qin| PDB=1qin | SIZE=400| SCENE= |right|CAPTION=Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion, [[1qin]] }} | ||
'''Glyoxalase''' (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism. | '''Glyoxalase''' (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism. <br /> | ||
* '''GLO1''' catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.<br /> | |||
* '''GLO2''' is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see [[Leishmania infantum Glyoxalase II]]. | |||
==3D structures of glyoxalase== | ==3D structures of glyoxalase== | ||