Tumor necrosis factor receptor: Difference between revisions
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== Function == | == Function == | ||
'''Tumor necrosis factor receptor''' (TNFR) or '''death receptor''' is a trimeric cytokine receptor which binds TNF. TNFR family contains several members and superfamily (TNFRSF) members. The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains. TNFRSF 6 is called '''Fas'''; TNFRSF 10B is called '''Dr5'''; TNFRSF 21 is called '''Dr6'''; TNFRSF 11A is called '''RANK'''; TNFRSF 18 is called '''GITRL'''. | '''Tumor necrosis factor receptor''' (TNFR) or '''death receptor''' is a trimeric cytokine receptor which binds TNF. TNFR family contains several members and superfamily (TNFRSF) members. The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains. '''TNFRSF 6''' is called '''Fas'''; '''TNFRSF 10B''' is called '''Dr5'''; '''TNFRSF 21''' is called '''Dr6'''; '''TNFRSF 11A''' is called '''RANK'''; '''TNFRSF 18''' is called '''GITRL'''. | ||
== Disease == | == Disease == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
===TNFR-1=== | |||
[[1ncf]] – hTNFR-1 residues 12-172 (mutant) – human<br /> | [[1ncf]] – hTNFR-1 residues 12-172 (mutant) – human<br /> | ||
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[[3ona]] – evTNFR SECRET domain + CX3CL1 <br /> | [[3ona]] – evTNFR SECRET domain + CX3CL1 <br /> | ||
===TNFRSF-1B=== | |||
[[3alq]] – hTNFRSF-1B extracellular domain + TNF<br /> | [[3alq]] – hTNFRSF-1B extracellular domain + TNF<br /> | ||
===TNFRSF-6 (Fas)=== | |||
[[3thm]], [[3tje]] – hTNFRSF-6 extracellular domain + antibody<br /> | [[3thm]], [[3tje]] – hTNFRSF-6 extracellular domain + antibody<br /> | ||
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[[3oq9]] – mTNFRSF-6 Fas DD domain + FADD - mouse<br /> | [[3oq9]] – mTNFRSF-6 Fas DD domain + FADD - mouse<br /> | ||
===TNFRSF-6B=== | |||
[[3mhd]] – hTNFRSF-6B extracellular domain <br /> | [[3mhd]] – hTNFRSF-6B extracellular domain <br /> | ||
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[[3k51]] – hTNFRSF-6B cysteine-rich domain + hTNFRSF-15 extracellular domain<br /> | [[3k51]] – hTNFRSF-6B cysteine-rich domain + hTNFRSF-15 extracellular domain<br /> | ||
===TNFRSF-10B (Dr5)=== | |||
[[2h9g]], [[4od2]], [[1za3]] – hTNFRSF-10B extracellular domain + antibody<br /> | [[2h9g]], [[4od2]], [[1za3]] – hTNFRSF-10B extracellular domain + antibody<br /> | ||
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[[1d4v]] – hTNFRSF-10B extracellular domain + TNF-related apoptosis inducing ligand<br /> | [[1d4v]] – hTNFRSF-10B extracellular domain + TNF-related apoptosis inducing ligand<br /> | ||
===TNFRSF-11A (RANK)=== | |||
[[3me4]] – mTNFRSF-11A extracellular domain <br /> | [[3me4]] – mTNFRSF-11A extracellular domain <br /> | ||
[[4giq]], [[3qbq]], [[3me2]] – mTNFRSF-11A extracellular domain + RANKL <br /> | [[4giq]], [[3qbq]], [[3me2]] – mTNFRSF-11A extracellular domain + RANKL <br /> | ||
===TNFRSF-12A=== | |||
[[2rpj]] – hTNFRSF-12A cysteine-rich domain – NMR <br /> | [[2rpj]] – hTNFRSF-12A cysteine-rich domain – NMR <br /> | ||
===TNFRSF-18 (GITRL)=== | |||
[[4db5]] – TNFRSF-18 – rabbit <br /> | [[4db5]] – TNFRSF-18 – rabbit <br /> | ||
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[[2r30]], [[2r32]] – hTNFRSF-18 extracellular domain (mutant) <br /> | [[2r30]], [[2r32]] – hTNFRSF-18 extracellular domain (mutant) <br /> | ||
===TNFRSF-21 (Dr6)=== | |||
[[3u3p]], [[3u3q]], [[3u3s]], [[3u3t]], [[3u3v]] – hTNFRSF-21 cysteine-rich domain<br /> | [[3u3p]], [[3u3q]], [[3u3s]], [[3u3t]], [[3u3v]] – hTNFRSF-21 cysteine-rich domain<br /> | ||
[[2dbh]] – hTNFRSF-21 CARD-like domain - NMR<br /> | [[2dbh]] – hTNFRSF-21 CARD-like domain - NMR<br /> | ||
[[3qo4]] – hTNFRSF-21 residues 42-218<br /> | [[3qo4]] – hTNFRSF-21 residues 42-218<br /> | ||
== References == | == References == | ||
Revision as of 11:42, 21 August 2014
<StructureSection load='2q1m' size='340' side='right' caption='Structure of human TNFRSF-18 extracellular domain (PDB code 2q1m).' scene=>
FunctionFunction
Tumor necrosis factor receptor (TNFR) or death receptor is a trimeric cytokine receptor which binds TNF. TNFR family contains several members and superfamily (TNFRSF) members. The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains. TNFRSF 6 is called Fas; TNFRSF 10B is called Dr5; TNFRSF 21 is called Dr6; TNFRSF 11A is called RANK; TNFRSF 18 is called GITRL.
DiseaseDisease
RelevanceRelevance
Structural highlightsStructural highlights
3D structures of tumor necrosis factor receptor3D structures of tumor necrosis factor receptor
Updated on 21-August-2014
TNFR-1TNFR-1
1ncf – hTNFR-1 residues 12-172 (mutant) – human
1ich – hTNFR-1 death domain (mutant) - NMR
2eqp – hTNFR-1 residues 28-70 – NMR
1ext – hTNFR-1 extracellular domain
1ft4 – hTNFR-1 extracellular domain + inhibitor
3on9 – evTNFR SECRET domain – ectromelia virus
3ona – evTNFR SECRET domain + CX3CL1
TNFRSF-1BTNFRSF-1B
3alq – hTNFRSF-1B extracellular domain + TNF
TNFRSF-6 (Fas)TNFRSF-6 (Fas)
3thm, 3tje – hTNFRSF-6 extracellular domain + antibody
3ezq – hTNFRSF-6 Fas DD domain + FADD
3oq9 – mTNFRSF-6 Fas DD domain + FADD - mouse
TNFRSF-6BTNFRSF-6B
3mhd – hTNFRSF-6B extracellular domain
4msv – hTNFRSF-6B extracellular domain + hTNFRSF-6 extracellular domain
4kgg, 4kgq, 4j6g – hTNFRSF-6B extracellular domain + hTNFRSF-14 extracellular domain
3mi8 – hTNFRSF-6B extracellular domain + hTNFRSF-15 extracellular domain
3k51 – hTNFRSF-6B cysteine-rich domain + hTNFRSF-15 extracellular domain
TNFRSF-10B (Dr5)TNFRSF-10B (Dr5)
2h9g, 4od2, 1za3 – hTNFRSF-10B extracellular domain + antibody
1d0g – hTNFRSF-10B extracellular domain + apoptosis-2 ligand
1d4v – hTNFRSF-10B extracellular domain + TNF-related apoptosis inducing ligand
TNFRSF-11A (RANK)TNFRSF-11A (RANK)
3me4 – mTNFRSF-11A extracellular domain
4giq, 3qbq, 3me2 – mTNFRSF-11A extracellular domain + RANKL
TNFRSF-12ATNFRSF-12A
2rpj – hTNFRSF-12A cysteine-rich domain – NMR
TNFRSF-18 (GITRL)TNFRSF-18 (GITRL)
4db5 – TNFRSF-18 – rabbit
4e4s – TNFRSF-18 – pika
4g4f – TNFRSF-18 – bushbaby
3fc0, 2qdn, 3b9i – mTNFRSF-18
2q1m – hTNFRSF-18 extracellular domain
2r30, 2r32 – hTNFRSF-18 extracellular domain (mutant)
TNFRSF-21 (Dr6)TNFRSF-21 (Dr6)
3u3p, 3u3q, 3u3s, 3u3t, 3u3v – hTNFRSF-21 cysteine-rich domain
2dbh – hTNFRSF-21 CARD-like domain - NMR
3qo4 – hTNFRSF-21 residues 42-218