Mitogen-activated protein kinase: Difference between revisions
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{{STRUCTURE_1erk| right| PDB=1erk | SCENE=Mitogen-activated_protein_kinase/Cv/1 |CAPTION=Mitogen-activated protein kinase, [[1erk]] }} | {{STRUCTURE_1erk| right| PDB=1erk | SCENE=Mitogen-activated_protein_kinase/Cv/1 |CAPTION=Mitogen-activated protein kinase, [[1erk]] }} | ||
[[Mitogen-activated protein kinase]] (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation. MAPK1 and MAPK3 are activated in response to growth factors. For MAPK2 representations see [[Michael Roberts/BIOL115/ERK2]]. MAPK6 is activated by phorbol esters. MAPK7 is activated by stress stimuli. MAPK8, MAPK9, MAPK10 (called also c-Jun N-terminal kinase 3 or JNK3), MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. MAPK11 (also called p38-β MAPK), MAPK12 (also called p38-γ MAPK), MAPK13 (also called p38-δ MAPK), MAPK14(also called p38-α MAPK) belong to the class called p38 MAPK. images on the left and right correspond to one representative MAPK structure, ''i.e.'' the rat MAPK1 ([[1erk]]). | [[Mitogen-activated protein kinase]] (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation. MAPK1 and MAPK3 are activated in response to growth factors. For MAPK2 representations see [[Michael Roberts/BIOL115/ERK2]]. MAPK6 is activated by phorbol esters. MAPK7 is activated by stress stimuli. MAPK8, MAPK9, MAPK10 (called also c-Jun N-terminal kinase 3 or JNK3), MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. MAPK11 (also called p38-β MAPK), MAPK12 (also called p38-γ MAPK), MAPK13 (also called p38-δ MAPK), MAPK14(also called p38-α MAPK) belong to the class called p38 MAPK. images on the left and right correspond to one representative MAPK structure, ''i.e.'' the rat MAPK1 ([[1erk]]). | ||
== 3D Structures of Mitogen-activated protein kinase == | == 3D Structures of Mitogen-activated protein kinase == | ||
Revision as of 11:35, 19 August 2014
Mitogen-activated protein kinase (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, MAP2K and MAP3K which are activated by phosphorylation. MAPK1 and MAPK3 are activated in response to growth factors. For MAPK2 representations see Michael Roberts/BIOL115/ERK2. MAPK6 is activated by phorbol esters. MAPK7 is activated by stress stimuli. MAPK8, MAPK9, MAPK10 (called also c-Jun N-terminal kinase 3 or JNK3), MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. MAPK11 (also called p38-β MAPK), MAPK12 (also called p38-γ MAPK), MAPK13 (also called p38-δ MAPK), MAPK14(also called p38-α MAPK) belong to the class called p38 MAPK. images on the left and right correspond to one representative MAPK structure, i.e. the rat MAPK1 (1erk).
3D Structures of Mitogen-activated protein kinase3D Structures of Mitogen-activated protein kinase
Updated on 19-August-2014
MAPK1MAPK1
4g6n, 4g6o, 4gsb – hMAPK1 - human
3i5z, 3i60, 2e14, 2ojg, 2oji, 2ojj, 1wzy, 1tvo, 3sa0, 4fux, 4fuy, 4fv0, 4fv1, 4fv2, 4fv3, 4fv4, 4fv5, 4fv6, 4fv7, 4fv8, 4fv9 – hMAPK1+inhibitor - human
2y9q – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide
3tei – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1
4iz5, 4iz7, 4iza – hMAPK1 (mutant) + astrocytic phosphoprotein
4fmq – hMAPK1 + MAPK docking peptide
4h3q – hMAPK1 + MAP2K 2 peptide
2z7l, 3c9w, 3qyw, 3qyz, 3qyi - rMAPK1+inhibitor – rat
1erk - rMAPK1
1gol, 3r63 - rMAPK1 (mutant)
2gph - rMAPK1 (mutant)+HEPTP (mutant)
3o71 - rMAPK1 + colorectal cancer peptide
2fys - rMAPK1 + KIM peptide
4gt3, 4gva – rMAPK1 + nucleotide
4i5h – rMAPK1 (mutant) + inhibitor
3o71 - rMAPK1 + colorectal cancer peptide
3zu7, 3zuv – rMAPK1 + ankyrin repeat protein
2y4i – raMAPK1+kinase suppressor of RAS 2 – rabbit
3oz6 - MAPK1 - Cryptosporidium parvum
MAPK2MAPK2
3gok - hMAPK2 kinase domain
2pzy, 2p3g, 2jbo, 2jbp – hMAPK2+inhibitor
3a2c, 3kc3, 3fpm, 3fyj, 3fyk - hMAPK2 kinase domain +inhibitor
3m2w, 3kga, 3ka0 – hMAPK2 kinase domain (mutant)+inhibitor
2oza, 2okr, 2onl – hMAPK2+ hMAPK14
2npt - hMAPK2+ hMAPK5
2erk – rMAPK2
3erk, 4erk – rMAPK2+inhibitor
MAPK3MAPK3
2zoq – hMAPK3
MAPK6MAPK6
3fxw, 3fhr – hMAPK3 kinase domain +inhibitor
2i6l – hMAPK6
MAPK7MAPK7
4ic8 – hMAPK7
4b99 – hMAPK7+inhibitor
4ic7 – hMAPK7+ MAP2K 5
MAPK8MAPK8
3o17, 2gmx, 2g01, 3vud, 3vug, 3vuh, 3vui, 3vuk, 3vul, 3vum – hMAPK8 (mutant)+JIP1 peptide
1ukh, 1uki - jMAPK8 JNK1+JIP1 peptide
3v3v - hMAPK8 JNK1+JIP1 peptide + quercedagetin
3o2m - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole
2xrw, 2xs0 - hMAPK8 + NFAT peptide
3elj, 3pze, 4awi, 4l7f - hMAPK8+inhibitor
4e73, 4g1w, 4hys, 4hyu, 4izy – hMAPK8 + JIP1 +inhibitor
2no3, 2h96 – hMAPK8 (mutant)+inhibitor
MAPK9MAPK9
3e7o - hMAPK9 (mutant)
3npc – hMAPK9 (mutant)+inhibitor
MAPK10MAPK10
3kvx, 3fv8, 2waj, 3fi2, 3fi3, 3da6, 2zdt, 2zdu, 3cgf, 3cgo, 2r9s, 2o0u, 2o2u, 2exc, 2b1p, 1pmn, 1pmq, 1pmu, 1pmv, 3oy1, 2ok1, 3ttj, 3tti, 3rtp, 3v6r, 3v6s – hMAPK10+inhibitor
3ptg, 4h39 - hMAPK10 catalytic domain + JIP1 peptide
4h36 – hMAPK10 catalytic domain + ATF2 peptide
4h3b – hMAPK10 catalytic domain + SAB peptide
1jnk – hMAPK10 catalytic domain + AMPPNP
3g9l, 3g90, 3g9n, 2p33 – hMAPK10 catalytic domain+inhibitor
3oxi - hMAPK10 + MAPK8 interacting protein + inhibitor
MAPK11MAPK11
3gp0 – hMAPK11+inhibitor
3gc8, 3gc9 – hMAPK11 (mutant)+inhibitor
MAPK13MAPK13
3coi, 4exu – hMAPK13
4eyj, 4eym - hMAPK13 +inhibitor
MAPK14MAPK14
3mgy, 3mh0, 3mh1, 3mh2, 3mh3, 3hvc, 3npq, 1wbo, 1r39, 2npq, 1wfc, 1cm8 – hMAPK14
2lgc – hMAPK14 – NMR
3od6, 3ody, 3odz, 3oef, 3p4k, 2fsl, 2fsm, 2fso, 2fst, 1r3c, 4e5a, 4geo – hMAPK14 (mutant)
3new, 3ocg, 3mvl, 3mvm, 3nnu, 3nnv, 3nnw, 3nnx, 3nww, 3mpt, 3lhj, 3huc, 3itz, 3l8x, 3kf7, 3fi4, 3fkl, 3fkn, 3fko, 3fl4, 3fln, 3flq, 3fls, 3flw, 3fly, 3flz, 3fmh, 3fmj, 3fmk, 3fml, 3flm, 3fln, 3fsf, 3fsk, 3kq7, 3iph, 3hv4, 3hv5, 3hv6, 3hv7, 3k3i, 3hec, 3heg, 3gi3, 3hp2, 3hp5, 3hrb, 3ha8, 3gfe, 3hl7, 3hll, 3gcu, 3fc1, 3dt1, 3e92, 3e93, 3d7z, 3d83, 3ctq, 2puu, 3bx5, 3c5u, 2zaz, 2zb0, 2zb1, 2qd9, 2ewa, 2gfs, 2baj, 2bak, 2bal, 2baq, 1zyj, 1wbn, 1wbs, 1wbt, 1wbv, 1wbw, 1zz2, 1zzl, 1yqj, 1w7h, 1w82, 1w83, 1w84, 1oz1, 1ouk, 1ouy, 1m7q, 1kv1, 1kv2, 1di9, 2rg5, 2rg6, 3bv3, 3bv2, 3fmm, 3fmn, 3lfa, 3mw1, 3pg3, 3roc ,2yis, 2yiw, 2yix, 3qud, 3que, 3rin, 3s3i, 3s4q, 3u8w, 3uvp, 3uvq, 3uvr, 3zs5, 3zsg, 3zsh, 3zsi, 3zya, 4a9y, 4aa0, 4aa4, 4aa5, 4aac, 4dli, 4dlj, 4e5b, 4eh2, 4eh3, 4eh4, 4eh5, 4eh6, 4eh7, 4eh8, 4eh9, 4ehv, 4ewq, 4f9w, 4f9y, 4fa2, 4kin, 4kip, 4kiq, 4l8m - hMAPK14+inhibitor
4e6a, 4e6c, 4e8a - hMAPK14+ lipid
3o8t, 3mpa, 3obg, 3o8u, 3o8p, 3obj, 3oc1, 3hub, 3l8s, 3hv3, 3iw5, 3iw6, 3iw7, 3iw8, 3k3j, 3gc7, 3gcp, 3gcq, 3gcs, 3gcv, 3ds6, 2i0h, 1ove, 3lfb, 3lfc, 3lfd, 3lfe, 3lff, 1bl6, 1bl7, 1bmk, 1a9u, 1ian - hMAPK14 (mutant)+inhibitor
2y8o – hMAPK14 (mutant) + dual specificity MAP2K peptide
4ka3, 4loo, 4lop, 4loq – hMAPK14 + docking peptide
3tg1 – hMAPK14 + MAPK phosphatase 5
2gtn, 2gtm, 3p5k, 3p78, 3p79, 3p7a, 3p7b, 3p7c - mMAPK14+inhibitor
2ghm, 2ghl, 1ywr - mMAPK14 (mutant)+inhibitor
3py3 - mMAPK14 phosphorylated
1yw2, 1p38 - mMAPK14 (mutant)
1lew - mMAPK14+MEF2A
1lez - mMAPK14+MKK3B
MAPK FUSSMAPK FUSS
2f9g, 2b9f – yMAPK FUSS – yeast
2fa2 – yMAPK FUSS (mutant)
2f49 - yMAPK FUSS+STE5 peptide
2b9h, 2b9i - yMAPK FUSS (mutant)+MSG5 peptide
2b9j - yMAPK FUSS (mutant)+FAR1 peptide
3rp9 – MAPK – Toxoplasma gondii
3uib – MAPK + inhibitor – Leishmania major