Histone methyltransferase: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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{{STRUCTURE_3s7j| PDB=3s7j | SIZE=400| SCENE= |right|CAPTION=Human histone-lysine N-methyltrasferase Smyd2 complex with S-adenosyl methionine, [[3s7j]] }} | {{STRUCTURE_3s7j| PDB=3s7j | SIZE=400| SCENE= |right|CAPTION=Human histone-lysine N-methyltrasferase Smyd2 complex with S-adenosyl methionine, [[3s7j]] }} | ||
'''Histone methyltransferase''' (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. | '''Histone methyltransferase''' (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. CxxC domain is a zinc finger domain. | ||
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[[3toj]] – hKHMT Ash2 Spry domain<br /> | [[3toj]] – hKHMT Ash2 Spry domain<br /> | ||
[[4ijd]] – hKHMT Prdm9<br /> | [[4ijd]] – hKHMT Prdm9<br /> | ||
[[4mi0]] – hKHMT Ezh2<br /> | |||
[[4mi5]] – hKHMT Ezh2 SET domain<br /> | |||
[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br /> | [[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br /> | ||
[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br /> | [[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br /> | ||
[[1u2z]] – yKHMT C terminal<br /> | [[1u2z]] – yKHMT C terminal<br /> | ||
[[2l7p]] – AtKHMT Ashh2 CW domain – ''Arabidopsis thaliana'' - NMR<br /> | [[2l7p]] – AtKHMT Ashh2 CW domain – ''Arabidopsis thaliana'' - NMR<br /> | ||
[[ | [[2lxe]] – AtKHMT Suvr4 SET31 - NMR<br /> | ||
===Histone-lysine N-methyltransferase binary complexes=== | ===Histone-lysine N-methyltransferase binary complexes=== | ||
[[2kkf]] – hKHMT Hrx CxxC domain +_DNA – NMR<br /> | [[2kkf]] – hKHMT Hrx CxxC domain +_DNA – NMR<br /> | ||
[[4nw3]] – hKHMT Mll CxxC domain + DNA <br /> | |||
[[4pzi]] – hKHMT CxxC domain + DNA <br /> | |||
[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain +_DNA <br /> | [[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain +_DNA <br /> | ||
[[3qow]] – hKHMT + SAM <br /> | [[3qow]] – hKHMT + SAM <br /> | ||
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[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br /> | [[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br /> | ||
[[3rib]] – hKHMT Smyd2 + SAH<br /> | [[3rib]] – hKHMT Smyd2 + SAH<br /> | ||
[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | |||
[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br /> | [[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br /> | ||
[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br /> | [[1n6a]] – hKHMT SET7/9 SET domain + SAM<br /> | ||
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[[3cbp]] - hKHMT SET7/9 SET domain + sinefungin<br /> | [[3cbp]] - hKHMT SET7/9 SET domain + sinefungin<br /> | ||
[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br /> | [[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br /> | ||
[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br /> | [[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br /> | ||
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[[3f9w]], [[3f9x]], [[3f9y]], [[3f9z]] - hKHMT SETD8 SET domain + SAH + H4 peptide<br /> | [[3f9w]], [[3f9x]], [[3f9y]], [[3f9z]] - hKHMT SETD8 SET domain + SAH + H4 peptide<br /> | ||
[[4ij8]] - hKHMT SETD8 + SAM + H3 peptide<br /> | [[4ij8]] - hKHMT SETD8 + SAM + H3 peptide<br /> | ||
[[4j7i]], [[4j83]], [[4j8o]] - hKHMT SETD7 + SAH + TFIID peptide<br /> | [[4j7i]], [[4j83]], [[4j8o]], [[4j7f]] - hKHMT SETD7 + SAH + TFIID peptide<br /> | ||
[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br /> | [[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br /> | ||
[[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + SAH + H3 peptide<br /> | [[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + SAH + H3 peptide<br /> | ||
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[[3s7b]] - hKHMT Smyd2 + SAM + inhibitor<br /> | [[3s7b]] - hKHMT Smyd2 + SAM + inhibitor<br /> | ||
[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br /> | [[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br /> | ||
[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br /> | |||
[[1zkk]] - hKHMT + SAH + H4 peptide <br /> | [[1zkk]] - hKHMT + SAH + H4 peptide <br /> | ||
[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br /> | [[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br /> | ||