Transferrin: Difference between revisions
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{{STRUCTURE_1jnf| PDB=1jnf | SIZE=400| SCENE= |right|CAPTION=Rabbit transferrin with Fe+3 (light red), carbonate and Cl- (green) ion, [[1jnf]] }} | {{STRUCTURE_1jnf| PDB=1jnf | SIZE=400| SCENE= |right|CAPTION=Rabbit transferrin with Fe+3 (light red), carbonate and Cl- (green) ion, [[1jnf]] }} | ||
'''Transferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues. TF contains two lobes: at the N and C termini. Ovotransferrin (OTF) is a glycosylated TF of egg white albumen. For details see [[Molecular Playground/Transferrin]]. | '''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues. TF contains two lobes: at the N and C termini. Ovotransferrin (OTF) is a glycosylated TF of egg white albumen. For details see [[Molecular Playground/Transferrin]]. | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
== 3D Structures of Transferrin == | == 3D Structures of Transferrin == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
===Transferrin=== | ===Transferrin=== | ||
[[1jnf]] – rTF - rabbit<br /> | [[1jnf]] – rTF - rabbit<br /> | ||
[[3qyt]], [[3v83]] – hTF + Fe+3 <br /> | |||
[[4h0w]] – hTF + Fe+3 + Bi+3<br /> | |||
[[1suv]] – hTF + TF receptor - human<br /> | [[1suv]] – hTF + TF receptor - human<br /> | ||
[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br /> | [[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br /> | ||
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[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br /> | [[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br /> | ||
[[1ryo]] - hTF N terminal + oxalate | [[1ryo]] - hTF N terminal + oxalate | ||
===Transferrin C lobe=== | |||
[[3skp]] – hTF C terminal<br /> | |||
===Apo transferrin=== | ===Apo transferrin=== | ||
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===Ovotransferrin=== | ===Ovotransferrin=== | ||
[[1ovt]], [[1n04]] – cOTF - chicken<br /> | [[1ovt]], [[1n04]] – cOTF + Fe+3 - chicken<br /> | ||
[[2d3i]] – cOTF | [[2d3i]] – cOTF + Al+3<br /> | ||
[[1dot]] – dOTF - duck | [[1dot]] – dOTF + Fe+3 - duck | ||
===Ovotransferrin N lobe=== | ===Ovotransferrin N lobe=== | ||
Revision as of 11:59, 22 May 2014
Transferrin or serotransferrin (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues. TF contains two lobes: at the N and C termini. Ovotransferrin (OTF) is a glycosylated TF of egg white albumen. For details see Molecular Playground/Transferrin.
3D Structures of Transferrin3D Structures of Transferrin
Updated on 22-May-2014
TransferrinTransferrin
1jnf – rTF - rabbit
3qyt, 3v83 – hTF + Fe+3
4h0w – hTF + Fe+3 + Bi+3
1suv – hTF + TF receptor - human
3s9l, 3s9m, 3s9n - hTF (mutant) + TF receptor
1h76 – TF - pig
Transferrin N lobeTransferrin N lobe
1tfd – rTF N terminal
1a8e, 1a8f, 1b3e, 1n84 - hTF N terminal
1dtg, 1d3k, 1d4n, 1fqe, 1fqf, 1jqf, 1n7w, 1n7x, 1oqg, 1oqh, 2o7u, 2o84, 3fgs - hTF N terminal (mutant)
1ryo - hTF N terminal + oxalate
Transferrin C lobeTransferrin C lobe
3skp – hTF C terminal
Apo transferrinApo transferrin
1bp5, 1btj - hTF N terminal
2hau, 2hav – hTF (mutant)
OvotransferrinOvotransferrin
1ovt, 1n04 – cOTF + Fe+3 - chicken
2d3i – cOTF + Al+3
1dot – dOTF + Fe+3 - duck
Ovotransferrin N lobeOvotransferrin N lobe
1ovb, 1gv8 – dOTF NII domain
1gvc - dOTF NII domain + nitrilotriacetate
1nnt, 1nft, 1iej – cOTF N terminal
Apo ovotransferrinApo ovotransferrin
1aov – dOTF
1aiv, 1ryx– cOTF
1tfa - cOTF N terminal
1iq7 - cOTF C terminal
1lfc – OTF residues 17-41 – bovine - NMR