4l4r: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
'''Unreleased structure'''
==Structural Characterisation of the Apo-form of Human Lactate Dehydrogenase M Isozyme==
<StructureSection load='4l4r' size='340' side='right' caption='[[4l4r]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
[[4l4r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4R OCA]. <br>
<b>Related:</b> [[4l4s|4l4s]]<br>
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
== Disease ==
[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref> 
== Function ==


The entry 4l4r is ON HOLD  until Paper Publication
== References ==
 
<references/>
Authors: Dempster, S., Harper, S., Moses, J.E., Dreveny, I.
__TOC__
 
</StructureSection>
Description: Structural Characterisation of the Apo-form of Human Lactate Dehydrogenase M Isozyme
[[Category: L-lactate dehydrogenase]]
[[Category: Dempster, S.]]
[[Category: Dreveny, I.]]
[[Category: Harper, S.]]
[[Category: Moses, J E.]]
[[Category: Anaerobic respiration]]
[[Category: Glycolysis]]
[[Category: Oxidoreductase]]

Revision as of 11:01, 30 April 2014

Structural Characterisation of the Apo-form of Human Lactate Dehydrogenase M IsozymeStructural Characterisation of the Apo-form of Human Lactate Dehydrogenase M Isozyme

Structural highlights

4l4r is a 2 chain structure. Full crystallographic information is available from OCA.

Related: 4l4s
Activity: Glucokinase, with EC number 2.7.1.2

Disease

[LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.[1]

Function

References

  1. ↑ Maekawa M, Sudo K, Kanno T, Li SS. Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency. Biochem Biophys Res Commun. 1990 Apr 30;168(2):677-82. PMID:2334430

4l4r, resolution 2.10Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4l4r&oldid=1920588"