1nw1: Difference between revisions

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-[[Image:1nw1.png|left|200px]]
+==Crystal Structure of Choline Kinase==
+<StructureSection load='1nw1' size='340' side='right' caption='[[1nw1]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
+== Structural highlights ==
+[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. <br>
+<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nw1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+<div style="clear:both"></div>
+== Publication Abstract from PubMed ==
+Choline kinase catalyzes the ATP-dependent phosphorylation of choline, the first committed step in the CDP-choline pathway for the biosynthesis of phosphatidylcholine. The 2.0 A crystal structure of a choline kinase from C. elegans (CKA-2) reveals that the enzyme is a homodimeric protein with each monomer organized into a two-domain fold. The structure is remarkably similar to those of protein kinases and aminoglycoside phosphotransferases, despite no significant similarity in amino acid sequence. Comparisons to the structures of other kinases suggest that ATP binds to CKA-2 in a pocket formed by highly conserved and catalytically important residues. In addition, a choline binding site is proposed to be near the ATP binding pocket and formed by several structurally flexible loops.
-{{STRUCTURE_1nw1|  PDB=1nw1  |  SCENE=  }}
+The crystal structure of choline kinase reveals a eukaryotic protein kinase fold.,Peisach D, Gee P, Kent C, Xu Z Structure. 2003 Jun;11(6):703-13. PMID:12791258<ref>PMID:12791258</ref>
-===Crystal Structure of Choline Kinase===
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+== References ==
-{{ABSTRACT_PUBMED_12791258}}
+<references/>
+__TOC__
-==About this Structure==
+</StructureSection>
-[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA].
+[[Category: Caeel]]
-==See Also==
-*[[Hemoglobin|Hemoglobin]]
-==Reference==
-<ref group="xtra">PMID:012791258</ref><ref group="xtra">PMID:015258570</ref><references group="xtra"/>
-[[Category: Caenorhabditis elegans]]
 [[Category: Choline kinase]]
 [[Category: Gee, P.]]