1nw1

Crystal Structure of Choline KinaseCrystal Structure of Choline Kinase

Structural highlights

1nw1 is a 2 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.02Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CKA2_CAEEL Catalyzes the first step in phosphatidylcholine biosynthesis. May contribute to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine but the activity is much higher with choline.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Gee P, Kent C. Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization. Biochim Biophys Acta. 2003 May 30;1648(1-2):33-42. PMID:12758145 doi:10.1016/s1570-9639(03)00106-7
↑ Yuan C, Kent C. Identification of critical residues of choline kinase A2 from Caenorhabditis elegans. J Biol Chem. 2004 Apr 23;279(17):17801-9. PMID:14960577 doi:10.1074/jbc.M401382200

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OCA

[1] Gee P, Kent C. Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization. Biochim Biophys Acta. 2003 May 30;1648(1-2):33-42. PMID:12758145 doi:10.1016/s1570-9639(03)00106-7

[2] Yuan C, Kent C. Identification of critical residues of choline kinase A2 from Caenorhabditis elegans. J Biol Chem. 2004 Apr 23;279(17):17801-9. PMID:14960577 doi:10.1074/jbc.M401382200

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