Sandbox Reserved 922: Difference between revisions

The <scene name='57/573136/Starting_view/1'>surface</scene> of FAAH reveals two equivalent openings (<scene name='57/573136/Starting_view/4'>Opening 1</scene>, <scene name='57/573136/Starting_view/5'>Opening 2</scene>) directly accessible by the inner layer of the [http://en.wikipedia.org/wiki/Lipid_bilayer lipid bilayer].<ref name= "1MT5">PMID:12459591</ref>  These <scene name='57/573136/Membrane_access_channel/8'>Membrane Access Channels</scene> (MAC) are made up of three flaps and two intrusions the which collectively allow the entry and aliphatic binding of the amide lipid substrate.  Flaps 1 and 2 envelope the middle and backside of the anandamide mimic, and are locked together by a <scene name='57/573136/Membrane_access_channel/9'>salt bridge</scene> between Arg486 and Asp403.  Flap 2 contains a very hydrophobic membrane binding cap that partially covers the entry way with Phe432.  This binding cap clings to the cell's inner membrane and lures out partitioned anandamide by attracting the substrate's narrow partially negatively charged head group with a multitude of positively charged residues.  its  each proceed by a respective membrane binding cap.  This sturdy flap appears to be loosened by the presence of five positively charged residues, and each MAC remains conformation-stable by a salt bridge.  The membrane access channel leads to the active site, which is flanked by  both the <scene name='57/573136/Cytosolic_port/2'>acyl chain binding pocket and cytosolic port </scene> (ABP and CP).<ref name= "3LJ7">PMID:20493882</ref>  The cytosolic port is a lengthy, flexible loop that leads directly into the [http://en.wikipedia.org/wiki/Cytoplasm cytoplasm], allowing the deacylated amine to enter the cell.