Sandbox Reserved 922

This Sandbox is Reserved from Jan 06, 2014, through Aug 22, 2014 for use by the Biochemistry II class at the Butler University at Indianapolis, IN USA taught by R. Jeremy Johnson. This reservation includes Sandbox Reserved 911 through Sandbox Reserved 922.

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This is the overall . The membrane access channel is accessible to lipids partitioned in the inner layer of the lipid bilayer. This is the . This is the . The of FAAH reveals two equivalent openings (, ) directly accessible by the inner layer of the lipid bilayer. These (MAC) are made up of three flaps and two intrusions which collectively form the entry way for the aliphatic binding of the amide lipid substrate. Flaps 1 and 2 envelope the middle and backside of the anandamide mimic, and are locked together by a between Arg486 and Asp403. Flap 2 contains a very that partially covers the opening with Phe432. This binding cap clings to the cell's hydrophobic inner membrane and uses a multitude of to lure out partitioned anandamide by its narrow partial negative charge. The catalytic site is defined by the catalytic triad: the contributes the nucleophilic S241, loop 3 contributes the neighboring upon forming the very top of the membrane access channel, and a fourth loop contributes the K142. The membrane access channel leads to the active site, which is flanked by both the (ABP and CP). The cytosolic port is a lengthy, flexible loop that leads directly into the cytoplasm, allowing the deacylated amine to enter the cell.

spinqualitylabelsall models Chains K and L from 1MT5 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

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