4by0: Difference between revisions

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OCA

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-'''Unreleased structure'''
+{{STRUCTURE_4by0|  PDB=4by0  |  SCENE=  }}
+===Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'- difluoro-(1,1'-biphenyl)-4-carboxamide===
-The entry 4by0 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/CP51_TRYCC CP51_TRYCC]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.<ref>PMID:16321980</ref> [UniProtKB:P0A512]
-Authors: Choi, J.Y., Calvet, C.M., Gunatilleke, S.S., Li, L., Cameron, M.D., Roush, W.R., McKerrow, J.H., Podust, L.M.
+==About this Structure==
+[[4by0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY0 OCA].
-Description: Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor ( R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4-carboxamide
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Sterol 14-demethylase]]
+[[Category: Calvet, C M.]]
+[[Category: Cameron, M D.]]
+[[Category: Choi, J Y.]]
+[[Category: Gunatilleke, S S.]]
+[[Category: McKerrow, J H.]]
+[[Category: Podust, L M.]]
+[[Category: Roush, W R.]]
+[[Category: Vierira, D F.]]
+[[Category: Chagas disease]]
+[[Category: Oxidoreductase]]
+[[Category: Sterol 14-demethylase]]
+[[Category: Sterol biosynthesis]]