Sandbox Reserved 820: Difference between revisions

Each monomere of CASQ2 can bind between <scene name='56/568018/Oligomere_and_ligand/12'>18 to 50 Ca2+</scene>. The Ca²⁺ ions bind to two or more acidic amino acids like <scene name='56/568018/Oligomere_and_ligand/13'>Glutamate</scene> or <scene name='56/568018/Oligomere_and_ligand/15'>Aspartate</scene>. These amino acids are mainly oriented outside and in the C-terminal region. It had been shown that Ca²⁺ions mainly binds an Asp-rich region on the disordered C-terminal domain. <!-- METTRE DU VERT MAIS LE CT N'EST PAS DISPONIBLE cf: http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=2VAF&bionumber=1 -->As CASQ2 form homooligomers, Ca²⁺ can be bound in the electronegative pockets created by the front-to-front and back-to-back dimer interactions.<ref name="The asp-rich region at the carboxyl-terminus of calsequestrin binds to Ca²⁺‡ and interacts with triadin (Shin et al., 2000)">The Asp-rich region at the carboxyl-terminus of calsequestrin binds to Ca²⁺ and interacts with triadin (Shin et al., 2000) http://www.sciencedirect.com/science/article/pii/S0014579300022468</ref>