Mandelate racemase: Difference between revisions

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<StructureSection load='3tte' size='400' side='right' caption='Structure of mandelate racemase dimer complex with mandelate, glycerol, formate, Mg+2 ion (PDB entry [[3tte]])' scene=''>
<StructureSection load='3tte' size='400' side='right' caption='Structure of mandelate racemase dimer complex with mandelate, glycerol, formate, Mg+2 ion (green)  (PDB entry [[3tte]])' scene=''>


'''Mandelate rasemase''' (MAR) catalyzes the interconversion of enantiomers of mandelate (S to R).  MAR is Mg-dependent.  MAR can racemize other alpha-hydroxy carbonyl compounds.  MAR is involved in aromatic acids catabolism.  
'''Mandelate rasemase''' (MAR) catalyzes the interconversion of enantiomers of mandelate (S to R).  MAR is Mg-dependent.  MAR can racemize other alpha-hydroxy carbonyl compounds.  MAR is involved in aromatic acids catabolism.  

Revision as of 13:18, 22 December 2013


Mandelate rasemase (MAR) catalyzes the interconversion of enantiomers of mandelate (S to R). MAR is Mg-dependent. MAR can racemize other alpha-hydroxy carbonyl compounds. MAR is involved in aromatic acids catabolism.

3D structures of mandelate racemase

2mnr – PpMAR – Pseudomonas putida

2hzg – MAR – Rhodobacter sphaeroides
2og9, 3bjs – MAR – Polaromonas
2pmq, 2rdx, 3u4f, 3fvd, 2qdd – MAR – Roseovarius
2qde – MAR – Azoarcus
3ik4 – MAR – Herpetosiphon aurantiacus
3mqt, 3sjn – MAR – Shewanella pealeana
3n4e, 4dwd – MAR – Paracoccus denitrificans
3n4f – GeMAR – Geobacillus
3msy, 3no1 – MAR – Marine actinobacterium
3n6h, 3n6j – MAR – Actinobacillus succinogenes
3ddm - MAR (mutant) – Bordetella bronchiseptica
3ssz – MAR – Rhodobacteraceae bacterium
3t4w – MAR – Sulfitobacter
3t8q – MAR – Hoeflea phototrophica
3u9i – MAR – Roseiflexus
4dx3, 4e8g, 3tj4, 3tji – AtMAR – Agrobacterium tumefaciens
3s47 – MAR – Clostridium beijerincki
4dhg, 3vc5, 3vc6 – MAR – Thermobispora bispora
4e4f – MAR – Pectobacterium carotovorum
3thu – MAR – Sphingomonas
3toy – BrMAR – Bradyrhizobium
3ugv – MAR – alpha proteobacterium
2pod – MAR – Burkholderia pseudomallei

Mandelate racemase binary complex

1mns, 1mdr – PpMAR + alpha phenyl glycidate

3ops – GeMAR + lactate
1mra, 1dtn – PpMAR (mutant) + atrolactate
1mdl - PpMAR (mutant) + mandelate
3tte - BrMAR + mandelate
3uxk, 3uxl – PpMAR + intermediate analog
3sbf – VbMAR (mutant) + arabinonate – Vibrionales bacterium
3r25 – VbMAR + glycerol
4gfi – AtMAR + dipeptide epimerase




Structure of mandelate racemase dimer complex with mandelate, glycerol, formate, Mg+2 ion (green) (PDB entry 3tte)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Karsten Theis