FunctionMandelate racemase (MAR) catalyzes the interconversion of enantiomers of mandelate (S to R). MAR is Mg-dependent. MAR can racemize other alpha-hydroxy carbonyl compounds. MAR is involved in aromatic acids catabolism[1].
Structural highlightsThe biological assembly of mandelate racemase from Pseudomonas putida is . The [2]. Water molecule are shown as red sphere.
| |
3D structures of mandelate racemase3D structures of mandelate racemase
Updated on 28-October-2021
{"openlevels":0}
- mandelate racemase
- 2mnr – PpMAR – Pseudomonas putida
- 2hzg – MAR – Rhodobacter sphaeroides
- 2og9, 3bjs – MAR – Polaromonas
- 2pmq, 2rdx, 3u4f, 3fvd, 2qdd – MAR – Roseovarius
- 2qde – MAR – Azoarcus
- 3ik4 – MAR – Herpetosiphon aurantiacus
- 3mqt, 3sjn – MAR – Shewanella pealeana
- 3n4e, 4dwd – MAR – Paracoccus denitrificans
- 3n4f – GeMAR – Geobacillus
- 3msy, 3no1 – MAR – Marine actinobacterium
- 3n6h, 3n6j – MAR – Actinobacillus succinogenes
- 3ddm - BbMAR (mutant) – Bordetella bronchiseptica
- 3h12 – BbMAR
- 3ssz – MAR – Rhodobacteraceae bacterium
- 3t4w – MAR – Sulfitobacter
- 3t8q – MAR – Hoeflea phototrophica
- 3u9i – MAR – Roseiflexus
- 4dx3, 4e8g, 3tj4, 3tji – AtMAR – Agrobacterium tumefaciens
- 3s47 – MAR – Clostridium beijerincki
- 4dhg, 3vc5, 3vc6 – MAR – Thermobispora bispora
- 4e4f – MAR – Pectobacterium carotovorum
- 3thu – MAR – Sphingomonas
- 3toy – BrMAR – Bradyrhizobium
- 3ugv – MAR – alpha proteobacterium
- 2pod – MAR – Burkholderia pseudomallei
- 3dfh - VbMAR – Vibrionales bacterium
- Mandelate racemase binary complex
- 1mns, 1mdr – PpMAR + α-phenyl lactate
- 1mra, 1dtn – PpMAR (mutant) + atrolactate
- 1mdl - PpMAR (mutant) + mandelate
- 4hnc - PpMAR (mutant) + benzilic acid
- 4m6u - PpMAR + tartronic acid
- 4fp1 – PpMAR + inhibitor
- 4x2p – PpMAR + 3-hydroxypyruvate
- 6vim, 7mqx – PpMAR + boronic acid derivative
- 3uxk, 3uxl – PpMAR + intermediate analog
- 3sbf – VbMAR (mutant) + arabinonate
- 3r25 – VbMAR + glycerol
- 4gfi – AtMAR + dipeptide epimerase
- 4h19 – AtMAR + ribonohydroxamate
- 3ops – GeMAR + lactate
- 3tte - BrMAR + mandelate
ReferencesReferences
- ↑ Powers VM, Koo CW, Kenyon GL, Gerlt JA, Kozarich JW. Mechanism of the reaction catalyzed by mandelate racemase. 1. Chemical and kinetic evidence for a two-base mechanism. Biochemistry. 1991 Sep 24;30(38):9255-63. PMID:1892833
- ↑ Landro JA, Gerlt JA, Kozarich JW, Koo CW, Shah VJ, Kenyon GL, Neidhart DJ, Fujita S, Petsko GA. The role of lysine 166 in the mechanism of mandelate racemase from Pseudomonas putida: mechanistic and crystallographic evidence for stereospecific alkylation by (R)-alpha-phenylglycidate. Biochemistry. 1994 Jan 25;33(3):635-43. PMID:8292591
proteopedia link