Stromal Derived Factor 1

NMR Structure of the Stromal cell-derived factor 1α, 2kec

spinqualitylabelsall models PDB ID 1qg7 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
Stromal cell-derived factor 1α dimer complex with sulfate, 1qg7
Ligands:
Structural annotation: Resources: CATH : 1Qg7A00, 1Qg7B00 InterPro : Ipr002473, Ipr001089, Ipr001811 Pfam : PF00048 SCOP : d1qg7a_, d1qg7b_ UniProt : P48061
Functional annotation: Cellular component: extracellular region extracellular space Biological process: chemotaxis G-protein coupled receptor protein signaling pathway cellular calcium ion homeostasis regulation of actin polymerization and/or depolymerization blood circulation response to virus cell-cell signaling cell adhesion immune response signal transduction inflammatory response Molecular function: receptor binding cytokine activity chemokine activity growth factor activity signal transducer activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Stromal Derived Factor 1 (SDF-1α) or CXCL12 is a small cytokine from the chemokine family. It is natural ligand of CXCR4 It has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis. The images on the left and right correspond to one representative SDF-1α structure, i.e. the human SDF-1α (2kec).

3D Structures of Stromal Derived Factor 13D Structures of Stromal Derived Factor 1

Updated on 19-December-2013

2kec, 2ked, 2kee, 2sdf, 1sdf, 1vmc - hSDF1α – NMR - human
1qg7, 3hp3 - hSDF1α
2k0l, 2k01, 2kol – hSDF1α (mutant) – NMR
1a15, 3gv3 - hSDF1α (mutant)
2nwg - hSDF1α+heparin
2j7z - hSDF1α residues 22-89
2k03, 2k04, 2k05 - hSDF1α (mutant)+ hCXCR4 N-terminal (mutant)