CXC chemokine receptor type 4

CXC chemokine receptors bind to cytokines of the CXC chemokine family. CXCR4 is specific for Stromal Derived Factor 1 (SDF-1α, known also as CXCL12). The CXCR4 is used by HIV to infect CD4+ T cells. The biological unit probably is a . CXCR1 recognizes CXC chemokines with ELR amino acids adjacent to the C-terminal CXC motif. (PDB code 3oe0). . . See also: Receptor Transmembrane (cell surface) receptors G protein-coupled receptors

spinqualitylabelsall models Human CXCR4/lysozyme chimera complex with cyclic peptide antagonist CVX15 (PDB code 3oe0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of CXC chemokine receptor type 43D Structures of CXC chemokine receptor type 4

Updated on 13-September-2021

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• CXC chemokine receptor type 4
  • 3odu – hCXCR4 residues 2-229 (mutant)/lysozyme residues 1002-1161+antagonist – human
    
  • 3oe0, 3oe6, 3oe8, 3oe9, 4rws – hCXCR4 residues 2-229 (mutant)/lysozyme residues 1002-1161/hCXCR4 residues 231-319+antagonist
    
  • 2k03, 2k04, 2k05 - hCXCR4 N-terminal (mutant)+hSDF-1 (mutant) - NMR
    
  • 2n55– hCXCR4 N-terminal + stromal cell-derived factor 1