Fibrinogen: Difference between revisions
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<applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Starting_scene/1" caption= 'Crystal structure of glycosylated fibrinogen fragment D. Subunit α (blue), β (green), γ (magenta) complex with the peptide ligand Gly-Pro-Arg-Pro-amide and Ca+2 ion, [[3hus]]' /> | <applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Starting_scene/1" caption= 'Crystal structure of glycosylated fibrinogen fragment D. Subunit α (blue), β (green), γ (magenta) complex with the peptide ligand Gly-Pro-Arg-Pro-amide and Ca+2 ion, [[3hus]]' /> | ||
{{ | {{STRUCTURE_2xnx| PDB=2xnx | SIZE=350| SCENE= |right|CAPTION=Acetyl-CoA synthase with Fe4S4 center complex with glycerol and Ni+2 ion [[2xnx]].}} | ||
Revision as of 14:02, 11 December 2013
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Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. [1] It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. [2]
3D Structure of Fibrinogen3D Structure of Fibrinogen
Updated on 11-December-2013
Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (, , ).
Fibrinogen α+β+γ chainsFibrinogen α+β+γ chains
3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
2xnx, 2xny - hFba+hFbb+hFbg + M1 protein
2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
1jy3, 1deq – cFba+cFbb+cFbg – cow
1jy2 - cFba+cFbb+cFbg proteolytic fragment
1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
1m1j - heFba+heFbb+heFbg+peptide ligand – hen
1ei3 - heFba+heFbb+heFbg
Fibrinogen α chainFibrinogen α chain
1fzd – hFba EC domain
1bbr – hFba+cε-thrombin
2jor – cFba – NMR
2baf – cFba
Fibrinogen β chainFibrinogen β chain
1fzf, 1fzg – hFb fragment double-D +peptide ligand
1fze, 1fza, 1fzb – hFb fragment D
Fibrinogen γ chainFibrinogen γ chain
2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains
2fib, 3fib - hFbg+peptide ligand
1fib – hFbg+Ca
1fic, 1fid – hFbg
3fib – hFbg C terminal
1dug – Fbg C-terminal/glutathione S-transferase – Schistosoma japonicum
2hwl – hFbg peptide+prothrombin
ReferencesReferences
- ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
- ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233