Integrin

<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrein CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry 1zoo)' scene=>

Integrins (IG) are receptors which mediate the attachment between cells or to extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain α (or CD49a) and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain.

3D structures of integrin3D structures of integrin

Updated on 01-July-2013

IG CR3IG CR3

1ido – hIG I domain + Mg – human
1jlm - hIG I domain + Mn

IG CD11aIG CD11a

1lfa - hIG I domain + Mn
1zon - hIG I domain
1zoo, 1zop, 3f74 - hIG I domain + Mg
1mq9 - hIG I domain (mutant) + Mn
1mjn - hIG I domain (mutant) + Mg
1mqa - hIG I domain (mutant)
2k8o – hIG cytoplasmic domain (mutant) – NMR

IG CD11a complexes

1cqp - hIG I domain + lovastatin + Mg
1mq8, 3bn3, 3tcx - hIG I domain (mutant) + intracellular adhesion molecule + Mg
1t0p - hIG I domain + intracellular adhesion molecule-3 + Mg
1rd4, 2ica, 3bqm, 3bqn, 3e2m - hIG I domain + inhibitor
2o7n, 3m6f - hIG I domain + antagonist
1xdd, 1xdg, 1xuo - hIG I domain + inhibitor + Mg
3f78 - hIG I domain + anesthetic + Mg
3eoa, 3eob - hIG I domain + antibody
3hi6 - hIG I domain (mutant) + antibody + Mn

IG CD11bIG CD11b

1bho - hIG I domain + Mg
1bhq - hIG I domain + Cd
1m1u - hIG I domain (mutant) + Ca
1n9z - hIG I domain (mutant) + Mg
1idn, 1na5 - hIG I domain
1mf7 - hIG I domain (mutant)

IG CD11cIG CD11c

1n3y - hIG I domain (mutant)

IG α-1IG α-1

1ck4 - rIG I domain – rat
4a0q - hIG I domain (mutant) + Mg
2l8s - hIG transmembrane domain – NMR
1mhp - rIG I domain (mutant) + antibody + Mn

IG α-2IG α-2

1dzi - hIG I domain + collagen peptide
1v7p - hIG I domain (mutant) + EMS16 + Mn

IG α-2bIG α-2b

2k1a - hIG transmembrane domain – NMR

IG α-MIG α-M

2lke, 2lkj – hIG cytoplasmic domain – NMR

IG α-XIG α-X

2luv – hIG cytoplasmic domain – NMR

IG α-1 β-1IG α-1 β-1

1qc5, 1qcy - hIG I domain (mutant) + Mg
1pt6 - hIG I domain + Mg

IG α-2 βIG α-2 β

1aox - hIG I domain (mutant) + Mg
1s4w - hIG cytoplasmic domain]] - NMR

IG α-2b β-3IG α-2b β-3

1kup, 1kuz – hIG proximal domain – NMR
1m8o - hIG cytoplasmic domain – NMR
2k9j, 2knc - hIG transmembrane domain – NMR
1tye, 3fcu – hIG + Mg
3fc3 – hIG (mutant) + Mg
2vc2, 2vdk, 2vdl, 3nid, 3nif, 3nig – hIG headpiece + antibody + Mg
2vdm, 2vdn, 3t3m, 3t3p – hIG headpiece + antibody + antagonist + Mg
2vdo, 2vdp, 2vdq, 2vdr – hIG headpiece + antibody + fibrinogen peptide + Mg

IG α-4 β-7IG α-4 β-7

3v4p - hIG headpiece (mutant) + antibody + Mg
3v4v - hIG headpiece (mutant) + antibody + inhibitor + Mg

IG α-5 β-1IG α-5 β-1

3vi3 - hIG headpiece + antibody + Mg
3vi4 - hIG headpiece + antibody + peptide + Mg

IG α-5 β-3IG α-5 β-3

3ije – hIG + Ca
1m1x - hIG extracellular domain + Mn
1u8c – hIG psi domain + Ca
1jv2 - hIG I domain + platelet membrane glycoprotein IIIA + Ca
1l5g - hIG I domain + tripeptide + Mn

IG α-X β-2IG α-X β-2

3k6s, 3k71, 3k72 – hIG + Mg

IG β-2IG β-2

2p26, 2p28 – hIG phe2 + phe3 domains

IG β-3IG β-3

1s4x, 2kv9, 2ljd, 2lje, 2ljf – hIG cytoplasmic domain – NMR
2rmz, 2rn0 – hIG transmembrane domain – NMR
2l91 - hIG transmembrane domain (mutant) – NMR

IG β-4IG β-4

2f7q, 3f7r - hIG fibronectin type III domain
2yrz – hIG fibronectin type III domain – NMR
3f7p - hIG fibronectin type III domain + plectin-1 + Ca
3fq4, 3fso, 3h6a – hIG Calx-β domain