Mitogen-activated protein kinase: Difference between revisions
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{{STRUCTURE_1erk| right| PDB=1erk | SCENE=Mitogen-activated_protein_kinase/Cv/1 |CAPTION=Mitogen-activated protein kinase, [[1erk]] }} | {{STRUCTURE_1erk| right| PDB=1erk | SCENE=Mitogen-activated_protein_kinase/Cv/1 |CAPTION=Mitogen-activated protein kinase, [[1erk]] }} | ||
[[Mitogen-activated protein kinase]] (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation. MAPK1 and MAPK3 are activated in response to growth factors. MAPK6 is activated by phorbol esters. MAPK7 is activated by stress stimuli. MAPK8, MAPK9, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. | [[Mitogen-activated protein kinase]] (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation. MAPK1 and MAPK3 are activated in response to growth factors. MAPK6 is activated by phorbol esters. MAPK7 is activated by stress stimuli. MAPK8, MAPK9, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. MAPK11, MAPK12, MAPK13, MAPK14 belong to the class called p38 MAPK. images on the left and right correspond to one representative MAPK structure, ''i.e.'' the rat MAPK1 ([[1erk]]). | ||
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Revision as of 11:34, 11 April 2013
Mitogen-activated protein kinase (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, MAP2K and MAP3K which are activated by phosphorylation. MAPK1 and MAPK3 are activated in response to growth factors. MAPK6 is activated by phorbol esters. MAPK7 is activated by stress stimuli. MAPK8, MAPK9, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. MAPK11, MAPK12, MAPK13, MAPK14 belong to the class called p38 MAPK. images on the left and right correspond to one representative MAPK structure, i.e. the rat MAPK1 (1erk).
3D Structures of Mitogen-activated protein kinase3D Structures of Mitogen-activated protein kinase
Update November 2011
MAPK1MAPK1
3i5z, 3i60, 2e14, 2ojg, 2oji, 2ojj, 2ok1, 1wzy, 1tvo – hMAPK1+inhibitor - human
2z7l, 3c9w, 3qyw, 3qyz - rMAPK1+inhibitor – rat
1erk - rMAPK1
1gol, 3r63 - rMAPK1 (mutant)
2gph - rMAPK1 (mutant)+HEPTP (mutant)
3o71 - rMAPK1 + colorectal cancer peptide
2fys - rMAPK1 + KIM peptide
2y4i – raMAPK1+kinase suppressor of RAS 2 – rabbit
3oz6 - MAPK1 - Cryptosporidium parvum
MAPK2MAPK2
3gok - hMAPK2 kinase domain
2pzy, 2p3g, 2jbo, 2jbp – hMAPK2+inhibitor
3a2c, 3kc3, 3fpm, 3fyj, 3fyk - hMAPK2 kinase domain +inhibitor
3m2w, 3kga, 3ka0 – hMAPK2 kinase domain (mutant)+inhibitor
2oza, 2okr, 2onl – hMAPK2+ hMAPK14
2npt - hMAPK2+ hMAPK5
2erk – rMAPK2
3erk, 4erk – rMAPK2+inhibitor
MAPK3MAPK3
2zoq – hMAPK3
MAPK6MAPK6
3fxw, 3fhr – hMAPK3 kinase domain +inhibitor
2i6l – hMAPK6
MAPK7MAPK7
2q8y - MAPK7+Virulence protein
MAPK8MAPK8
3o17, 2gmx, 2g01 – hMAPK8 (mutant)+JIP1 peptide
1ukh, 1uki - jMAPK8 JNK1+JIP1 peptide
3o2m - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole
2xrw, 2xs0 - hMAPK8 + NFAT peptide
3elj - hMAPK8+inhibitor
2no3, 2h96 – hMAPK8 (mutant)+inhibitor
MAPK9MAPK9
3e7o - hMAPK9 (mutant)
3npc – hMAPK9 (mutant)+inhibitor
MAPK10MAPK10
3kvx, 3fv8, 2waj, 3fi2, 3fi3, 3da6, 2zdt, 2zdu, 3cgf, 3cgo, 2r9s, 2o0u, 2o2u, 2exc, 2b1p, 1pmn, 1pmq, 1pmu, 1pmv, 3oy1 – hMAPK10+inhibitor
3ptg - hMAPK10+JIP1 peptide
3g9l, 3g90, 3g9n, 2p33 – hMAPK10 kinase domain+inhibitor
3oxi - hMAPK10 + MAPK8 interacting protein + inhibitor
MAPK11MAPK11
3gp0 – hMAPK11+inhibitor
3gc8, 3gc9 – hMAPK11 (mutant)+inhibitor
MAPK13MAPK13
3coi – hMAPK13
MAPK14MAPK14
3mgy, 3mh0, 3mh1, 3mh2, 3mh3, 3hvc, 3npq, 1wbo, 1r39, 2npq – hMAPK14
3od6, 3ody, 3odz, 3oef, 3p4k, 2fsl, 2fsm, 2fso, 2fst, 1r3c – hMAPK14 (mutant)
3new, 3ocg, 3mvl, 3mvm, 3nnu, 3nnv, 3nnw, 3nnx, 3nww, 3mpt, 3lhj, 3huc, 3itz, 3l8x, 3kf7, 3fi4, 3fkl, 3fkn, 3fko, 3fl4, 3fln, 3flq, 3fls, 3flw, 3fly, 3flz, 3fmh, 3fmj, 3fmk, 3fml, 3flm, 3fln, 3fsf, 3fsk, 3kq7, 3iph, 3hv4, 3hv5, 3hv6, 3hv7, 3k3i, 3hec, 3heg, 3gi3, 3hp2, 3hp5, 3hrb, 3ha8, 3gfe, 3hl7, 3hll, 3gcu, 3fc1, 3dt1, 3e92, 3e93, 3d7z, 3d83, 3ctq, 2puu, 3bx5, 3c5u, 2zaz, 2zb0, 2zb1, 2qd9, 2ewa, 2gfs, 2baj, 2bak, 2bal, 2baq, 1zyj, 1wbn, 1wbs, 1wbt, 1wbv, 1wbw, 1zz2, 1zzl, 1yqj, 1w7h, 1w82, 1w83, 1w84, 1oz1, 1ouk, 1ouy, 1m7q, 1kv1, 1kv2, 1di9, 2rg5, 2rg6, 3bv3, 3bv2, 3fmm, 3fmn, 3lfa, 3mw1, 3pg3, 3roc - hMAPK14+inhibitor
3o8t, 3mpa, 3obg, 3o8u, 3o8p, 3obj, 3oc1, 3hub, 3l8s, 3hv3, 3iw5, 3iw6, 3iw7, 3iw8, 3k3j, 3gc7, 3gcp, 3gcq, 3gcs, 3gcv, 3ds6, 2i0h, 1ove, 3lfb, 3lfc, 3lfd, 3lfe, 3lff - hMAPK14 (mutant)+inhibitor
2gtn, 2gtm, 3p5k, 3p78, 3p79, 3p7a, 3p7b, 3p7c - mMAPK14+inhibitor
2ghm, 2ghl, 1ywr - mMAPK14 (mutant)+inhibitor
3py3 - mMAPK14 phosphorylated
1yw2 - mMAPK14 (mutant)
1lew - mMAPK14+MEF2A
1lez - mMAPK14+MKK3B
MAPK p38MAPK p38
1wfc - hMAPK p38
1bl6, 1bl7, 1bmk, 1a9u, 1ian – hMAPK p38 (mutant)+inhibitor
1p38 - mMAPK p38 (mutant) - mouse
MAPK FUSSMAPK FUSS
2f9g, 2b9f – yMAPK FUSS – yeast
2fa2 – yMAPK FUSS (mutant)
2f49 - yMAPK FUSS+STE5 peptide
2b9h, 2b9i - yMAPK FUSS (mutant)+MSG5 peptide
2b9j - yMAPK FUSS (mutant)+FAR1 peptide
3rp9 – MAPK – Toxoplasma gondii