Histone methyltransferase: Difference between revisions
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== 3D Structures of histone methyltransferase == | == 3D Structures of histone methyltransferase == | ||
''Updated | ''Updated February 2013'' | ||
[[1nw3]] – hHMT DOT1L – human | [[1nw3]] – hHMT DOT1L – human | ||
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[[3s8p]] - hKHMT Suv420H1<br /> | [[3s8p]] - hKHMT Suv420H1<br /> | ||
[[3mts]] - hKHMT Suv39H1 chromo domain<br /> | [[3mts]] - hKHMT Suv39H1 chromo domain<br /> | ||
[[1h3i]] - hKHMT | [[1h3i]] - hKHMT Set7/9 residues 52-344<br /> | ||
[[2o8j]] - hKHMT H3K9 residues 913-1193<br /> | [[2o8j]] - hKHMT H3K9 residues 913-1193<br /> | ||
[[ | [[2lv9]] - hKHMT Mll5 residues 109-188 - NMR<br /> | ||
[[3n71]] - hKHMT Smyd1<br /> | [[3n71]] - hKHMT Smyd1<br /> | ||
[[ | [[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br /> | ||
[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br /> | |||
[[1u2z]] – yKHMT C terminal | |||
===Histone-lysine N-methyltransferase complexes=== | |||
[[3rib]] – hKHMT Smyd2 + SAH<br /> | |||
[[1o9s]] - hKHMT Set7/9 residues 52-344 + H3 peptide<br /> | |||
[[2bqz]] - hKHMT Set7 residues 192-352 + H4 peptide<br /> | |||
[[1mt6]] - hKHMT Set7/9 residues 58-337 + SAH<br /> | |||
[[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + H3 peptide<br /> | |||
[[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br /> | |||
[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br /> | |||
[[3s7b]] - hKHMT Smyd2 + SAM + inhibitor | [[3s7b]] - hKHMT Smyd2 + SAM + inhibitor | ||
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[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | [[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | ||
[[1peg]] - NcKHMT Dim-5 + H3 peptide<br /> | [[1peg]] - NcKHMT Dim-5 + H3 peptide<br /> | ||
[[2g46]] – PvKHMT + SAH + H3 peptide<br /> | [[2g46]] – PvKHMT + SAH + H3 peptide<br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 13:09, 6 February 2013
Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor.
3D Structures of histone methyltransferase3D Structures of histone methyltransferase
Updated February 2013
1nw3 – hHMT DOT1L – human
2igq – hHMT-1 C terminal
Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferase
2j8a – KHMT SET1 RRM domain – yeast
3s8s – hKHMT SETD1A RRM domain
2r3a – hKHMT Suv39H2
3rq4 - hKHMT Suv420H2
3s8p - hKHMT Suv420H1
3mts - hKHMT Suv39H1 chromo domain
1h3i - hKHMT Set7/9 residues 52-344
2o8j - hKHMT H3K9 residues 913-1193
2lv9 - hKHMT Mll5 residues 109-188 - NMR
3n71 - hKHMT Smyd1
1ml9 – NcKHMT Dim-5 – Neurospora crassa
1n3j – PvKHMT – Paramecium bursaria chlorella virus
1u2z – yKHMT C terminal
Histone-lysine N-methyltransferase complexesHistone-lysine N-methyltransferase complexes
3rib – hKHMT Smyd2 + SAH
1o9s - hKHMT Set7/9 residues 52-344 + H3 peptide
2bqz - hKHMT Set7 residues 192-352 + H4 peptide
1mt6 - hKHMT Set7/9 residues 58-337 + SAH
2rfi, 3hna - hKHMT H3K9 catalytic domain + H3 peptide
3b95 - hKHMT ankyrin repeat domain + H3 peptide
3lqi, 3lqj - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide
3s7b - hKHMT Smyd2 + SAM + inhibitor
3s7d, 3s7f, 3tg5 - hKHMT Smyd2 + SAH + p53 peptide
3s7j, 3tg4 - hKHMT Smyd2 + SAM
1peg - NcKHMT Dim-5 + H3 peptide
2g46 – PvKHMT + SAH + H3 peptide