DNA methyltransferase: Difference between revisions
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== 3D Structures of DNA methyltransferase == | == 3D Structures of DNA methyltransferase == | ||
''Updated | ''Updated January 2013'' | ||
===Methylguanine DNMT=== | ===Methylguanine DNMT=== | ||
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[[3a1b]] - h-cytosine DNMT ADD domain + histone H3 | [[3a1b]] - h-cytosine DNMT ADD domain + histone H3 | ||
[[3pt6]], [[3pt9]] – m-cytosine DNMT + DNA | [[3pt6]], [[3pt9]], [[4da4]] – m-cytosine DNMT + DNA | ||
[[3av5]] - m-cytosine DNMT + SAH | [[3av5]] - m-cytosine DNMT + SAH | ||
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[[2z6q]], [[2z6u]], [[2zcj]] - Hh-cytosine DNMT (mutant) + DNA + ADOHCY | [[2z6q]], [[2z6u]], [[2zcj]] - Hh-cytosine DNMT (mutant) + DNA + ADOHCY | ||
[[1svu]] - Hh-cytosine DNMT (mutant) | [[1svu]] - Hh-cytosine DNMT (mutant)<br /> | ||
[[4fsx]] – c-cytosine DNMT + SAH – corn<br /> | |||
[[4ft2]], [[4ft4]] – c-cytosine DNMT + histone H3 peptide<br /> | |||
[[4h0n]] - cytosine DNMT (mutant) – ''Spodoptera frugiperda'' | |||
===Methyladenine DNMT=== | ===Methyladenine DNMT=== | ||
Revision as of 15:59, 30 January 2013
DNA methyltransferase (DNMT) catalyzes the transfer of methyl group to DNA. DNMT uses S-adenosyl methionine (SAM) as the methyl donor. The SAM analog S-adenosyl homocysteine (SAH) is a powerful inhibitor of DNMT.
3D Structures of DNA methyltransferase3D Structures of DNA methyltransferase
Updated January 2013
Methylguanine DNMTMethylguanine DNMT
1sfe – O6-methylguanine DNMT C terminal – Escherichia coli
1qnt, 1eh6, 3llr - hO6-methylguanine DNMT – human
1t38 - hO6-methylguanine DNMT (mutant) + DNA
1t39, 1yfh - hO6-methylguanine DNMT + DNA
1eh7 - hO6-methylguanine DNMT methylated
1eh8 - hO6-methylguanine DNMT benzylated
1wrj - O6-methylguanine DNMT - Sulfolobus tokodaii
2g7h - O6-methylguanine DNMT – Methanocaldococcus jannaschii
2kif, 2kim - O6-methylguanine DNMT – Vibrio parahaemolyticus - NMR
Methylcytosine DNMTMethylcytosine DNMT
2qrv - h-cytosine DNMT
3epz - h-cytosine DNMT replecation foci-targeting sequence
3flg - h-cytosine DNMT ADD domain
3a1a - h-cytosine DNMT PWWP domain
1g55 - h-cytosine DNMT2 (mutant)
3qkj - h-cytosine DNMT 3β
3av4, 1khc - m-cytosine DNMT – mouse
2uyc, 2uyh, 2uz4 - Hh-cytosine DNMT (mutant) + DNA + SAH
3a1b - h-cytosine DNMT ADD domain + histone H3
3pt6, 3pt9, 4da4 – m-cytosine DNMT + DNA
3av5 - m-cytosine DNMT + SAH
3av6 - m-cytosine DNMT + SAM
3swr - h-cytosine DNMT + sinefungin
1boo - cytosine DNMT (mutant) – Proteus vulgaris
3qv2 - cytosine DNMT + SAH – Entamoeba histolytica
2uyc, 2uyh, 2uz4, 1fjx – Hh-cytosine DNMT (mutant) + DNA + SAH - Haemophilus haemolyticus
2c7o, 2c7p, 2c7q, 2c7r, 3pta – Hh-cytosine DNMT + DNA + S-adenonosyl cysteine
1hmy – Hh-cytosine Haeiii DNMT + SAM
1m0e - Hh-cytosine DNMT (mutant) + DNA + inhibitor
2i9k - Hh-cytosine DNMT (mutant) + DNA
2hr1 - Hh-cytosine DNMT + DNA + ADOHCY
2z6q, 2z6u, 2zcj - Hh-cytosine DNMT (mutant) + DNA + ADOHCY
1svu - Hh-cytosine DNMT (mutant)
4fsx – c-cytosine DNMT + SAH – corn
4ft2, 4ft4 – c-cytosine DNMT + histone H3 peptide
4h0n - cytosine DNMT (mutant) – Spodoptera frugiperda
Methyladenine DNMTMethyladenine DNMT
1nw5 – RsN6-adenine DNMT + SAM – Rhodobacter sphaeroides
1nw6 - RsN6-adenine DNMT + sinefungin
1nw7 - RsN6-adenine DNMT + SAH
1nw8 - RsN6-adenine DNMT (mutant)
2ibs, 2ibt, 2ih2, 2ih4, 2ih5, 2np6, 2np7, 1g38 - Ta-adenine DNMT Taqi + DNA + cofactor analog – Thermus aquaticus
1aqi – Ta-adenine DNMT Taqi + SAH
1aqj – Ta-adenine DNMT Taqi + sinefugin
2adm - Ta-adenine DNMT Taqi + SAM
1g60 - adenine DNMT + SAM – Moraxella bovis