Uridine 5'-monophosphate synthase: Difference between revisions
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{{STRUCTURE_2v30| PDB=2v30 | SIZE=400| SCENE= |right|CAPTION=Human uridine 5'-monophosphate synthase OPD subunit complex with UMP, [[2v30]] }} | {{STRUCTURE_2v30| PDB=2v30 | SIZE=400| SCENE= |right|CAPTION=Human uridine 5'-monophosphate synthase OPD subunit dimer complex with UMP, [[2v30]] }} | ||
'''Uridine 5’-monophosphate synthase''' (UMPS) is a bifunctional enzyme catalyzes the formation of uridine monophosphate (UMP). UMPS N-terminal domain is an orotate phosphoribosyl transferase (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP). The C-terminal subunit is orotidine 5’-phosphate decarboxylase (OPD) which decarboxylates OMP to form UMP. | '''Uridine 5’-monophosphate synthase''' (UMPS) is a bifunctional enzyme catalyzes the formation of uridine monophosphate (UMP). UMPS N-terminal domain is an orotate phosphoribosyl transferase (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP). The C-terminal subunit is orotidine 5’-phosphate decarboxylase (OPD) which decarboxylates OMP to form UMP. | ||
Revision as of 13:39, 3 January 2013
Uridine 5’-monophosphate synthase (UMPS) is a bifunctional enzyme catalyzes the formation of uridine monophosphate (UMP). UMPS N-terminal domain is an orotate phosphoribosyl transferase (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP). The C-terminal subunit is orotidine 5’-phosphate decarboxylase (OPD) which decarboxylates OMP to form UMP.
3D structures of uridine 5'-monophosphate synthase3D structures of uridine 5'-monophosphate synthase
Uridine 5’-monophosphate synthase OPD subunitUridine 5’-monophosphate synthase OPD subunit
3gdk - yOPD – yeast
1dqw, 3gdr, 3gdm – yOPD (mutant)
2eaw, 2jgy, 2p1f, 2qcc, 2qce - hOPD – human
Uridine 5’-monophosphate synthase OPD subunit complexUridine 5’-monophosphate synthase OPD subunit complex
2v30, 2qcd - hOPD + UMP
3ewy - hOPD (mutant) + UMP
3gdl - yOPD + UMP derivative
1dqx, 3gdt - yOPD (mutant) + UMP derivative
2qcg, 2qch, 3bgg, 3bgj, 3bk0, 3g3d, 3g3m, 3ewz, 3ex2, 3ex3, 3ex4, 3dbp, 3l0k, 3l0n, 3mo7, 3mw7 - hOPD + UMP derivative
3bvj - hOPD + xanthosine 5’-monophosphate
2qcf, 2qcm, 2qcn, 3ewu, 3ewx, 3ex6 - hOPD (mutant) + UMP derivative
3mi2, 4hib, 4hkp - hOPD + inhibitor
3ex1 - hOPD + UMP derivative + UMP
2qcl - yOPD (mutant) + OMP
Uridine 5’-monophosphate synthase OPRT subunit complexUridine 5’-monophosphate synthase OPRT subunit complex
2wns - hOPRT + OMP