Annexin: Difference between revisions
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[[Image:1ain.png|left|200px|thumb|Crystal Structure of Human Annexin I, [[1ain]]]] | [[Image:1ain.png|left|200px|thumb|Crystal Structure of Human Annexin I, [[1ain]]]] | ||
{{STRUCTURE_1ain| PDB=1ain | SIZE=400| SCENE=Annexin/Cv/2 |right|CAPTION=Human Annexin I complex with Ca+2 ions, [[1ain]] }} | {{STRUCTURE_1ain| PDB=1ain | SIZE=400| SCENE=Annexin/Cv/2 |right|CAPTION=Human Annexin I complex with Ca+2 ions, [[1ain]] }} | ||
[[Annexin|Annexins]] are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. They consist of 2 domains - the C-terminal core and the N-terminal head. Annexins divide into species and are numbered from I to XII. Annexin V is the most abundant scaffolding protein. Annexin E1 (AnE1) is associated with tubulin in trophozoites of ''Giardia lamblia'' and forms local slubs in the flagella. In the annexin image calcium ions are shown as green balls. | [[Annexin|Annexins]] are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. They consist of 2 domains - the C-terminal core and the N-terminal head. Annexins divide into species and are numbered from I to XII. Annexin V is the most abundant scaffolding protein. Annexin E1 (AnE1) is associated with tubulin in trophozoites of ''Giardia lamblia'' and forms local slubs in the flagella. In the annexin image calcium ions are shown as green balls. | ||
Revision as of 14:08, 11 December 2012
Annexins are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. They consist of 2 domains - the C-terminal core and the N-terminal head. Annexins divide into species and are numbered from I to XII. Annexin V is the most abundant scaffolding protein. Annexin E1 (AnE1) is associated with tubulin in trophozoites of Giardia lamblia and forms local slubs in the flagella. In the annexin image calcium ions are shown as green balls.
3D structures of annexin3D structures of annexin
Update May 2012
Annexin IAnnexin I
2q4c, 1ycn - AnI - Arabidopsis thaliana
1mcx, 1hm6 - pAnI - pig
1qls - pAnI head+calgizzarrin
1bo9 - hAnI head - human NMR
1ain - hAnI
Annexin IIAnnexin II
2hyu, 2hyv - hAnII+heparin oligosaccharide
2hyw, 1xjl - hAnII+Ca
1w7b - hAnII
1bt6 - hAnII head+calpactin light chain
Annexin IIIAnnexin III
Annexin IVAnnexin IV
2zhi, 2zhj, rAnIV+Na - rat
2zoc - hAnIV
1i4a - cAnIV (mutant) - cow
1aow, 1ann - cAnIV
Annexin VAnnexin V
2ie6, 2ie7, rAnV
1n41, 1n42, 1n44, 2h0k, 2h0l, 2h0m, 1bc0, 1bc1, 1bc3, 1bcw, 1bcy, 1bcz - rAnV (mutant)
1g5n - rAnV+ heparin oligosaccharide
1a8a, 1a8b - rAnV+phospholipid analog
2ran - rAnV+Ca
1yii – chAnV+Ca – chicken
1yj0 - chAnV+Zn
1ala - ChAnV
1hak - hAnV+K-201
1sav - hAnV (thioproline)
1hvd, 1hve, 1hvf, 1hvg - hAnV (mutant)
1anw, 1avh, 1avr - hAnV
1anx - hAnV+Ca
2xo2 – hAnV + Ca + azidohomoalanine
2xo3 - hAnV + Ca + homopropargylglycine
Annexin VIAnnexin VI
1m9i - hAnVI (mutant)
1avc - cAnVI+Ca
Annexin VIIIAnnexin VIII
1w3w - hAnVIII
1w45 - hAnVIII (mutant)
Annexin XIIAnnexin XII
1dm5 - HvAnXII (mutant) - Hydra vulgaris
1aei - HvAnXII
Annexin E1Annexin E1
3chj – GlAnE1 – Giardia lamblia
3chk, 3chl – GlAnE1 + cation
Other annexinsOther annexins
1dk5 - An24 - Capsicom annuum
3brx - coAnGH1+Ca - cotton
1n00 - coAnGH1