Virus coat protein: Difference between revisions

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<StructureSection load='3gv2' size='400' side='right' caption='Structure of HIV-I coat protein (PDB entry [[3gv2]])' scene=''>
<StructureSection load='3gv2' size='400' side='right' caption='Structure of HIV-I coat protein hexamer (PDB entry [[3gv2]])' scene=''>


'''Virus coat proteins''' (VCP) or capsid proteins coat the virus.  The various VCPs are designated as Vp1, Vp2, etc.  The VCP P domain (protruding domain) in noroviruses binds histo blood group antigen receptors.
'''Virus coat proteins''' (VCP) or capsid proteins coat the virus.  The various VCPs are designated as Vp1, Vp2, etc.  The VCP P domain (protruding domain) in noroviruses binds histo blood group antigen receptors.

Revision as of 15:22, 10 December 2012


Virus coat proteins (VCP) or capsid proteins coat the virus. The various VCPs are designated as Vp1, Vp2, etc. The VCP P domain (protruding domain) in noroviruses binds histo blood group antigen receptors.

3D structures of virus coat proteins

VCP of parvovirus

2cas – cpvVCP - canine parvovirus

1s58 - VCP – human parvovirus
1k3v – VCP Vp2 – pig parvovirus
1ijs, 1p5w, 1p5y – cpvVCP (mutant) + DNA
4dpv - cpvVCP + DNA

VCP of HIV

1afv, 1e6j – HivVCP + antibody – HIV-1

3gv2, 3h47, 3h4e – HivVCP (mutant)
1aum, 1a8o, 1a43, 2ont, 3lry, 3mge – HivVCP C terminal
2jyl, 2jyg - HivVCP C terminal (mutant) – NMR
3dph, 3ds2, 3ds5, 3dtj - HivVCP C terminal (mutant)
2buo - HivVCP C terminal + inhibitor of capsid assembly
2xt1, 2xv6, 2xxm - HivVCP C terminal + camelid VHH 9
3ds0, 3ds1, 3ds3, 3ds4 - HivVCP C terminal (mutant) + inhibitor of capsid assembly
1m9c, 1m9d - HivVCP N terminal + cyclophilin
1m9e, 1m9f, 1m9x, 1m9y - HivVCP N terminal (mutant)+ cyclophilin
2x82, 2x83 – VCP N terminal – HIV-2

VCP of Rous sarcoma virus

1d1d – RsvVCP – Rous sarcoma virus – NMR

1em9, 1p7n – RsvVCP N terminal
1eoq, 3g1g, 3g1i, 3g21, 2x8q - RsvVCP C terminal
3g0v, 3g26, 3g28, 3g29 - RsvVCP C terminal (mutant)
3tir – RsvVCP P27

VCP of rotavirus

1qhd – brvVCP Vp6 – bovine rotavirus

3kz4 - brvVCP Vp2
2b4h, 2b4i, 2p3i, 2p3k - rrVCP Vp4 – rhesus rotavirus
2p3j – rrVCP Vp4 (mutant)
3gzt, 3gzu – rrVCP Vp7 – Cryo EM
2i2s, 3sis, 3sit - VCP Vp4 – pig rotavirus
2dwr - hrvVCP Vp8* – human rotavirus
4drr, 4drv, 4ds0 - hrvVCP Vp8* + antigen

VCP of hepatitis virus

1qgt, 2qij – hbvVCP – hepatitis B virus

3kxs – hbvVCP (mutant)
2ztn, 3ggq, 2zzq, 3rkc - hevVCP – hepatitis E virus
3rkd – hevVCP + antibody
3iyo – hevVCP – Cryo EM

VCP of norovirus

1ihm, 3by1, 3by2, 3d26, 2zl5, 2zl6, 2zl7 – NvVCP – Norwalk virus

3onu, 3ony, 2obr, 2obs, 2obt, 3lq6, 3lqe, 3ry8 – NvVCP P domain
3pa1, 3pa2, 3q38, 3q39, 3q3a, 3q6q, 3q6r, 3asp, 3asq, 3asr, 3ass, 3ast - NvVCP P domain + antigen
3m8l – VCP – feline calcivirus
3v7a – NvVCP P domain + antibody

VCP of plant viruses

1js9, 1yc6 – VCP – brome mosaic virus

1f15 – VCP – cucumber mosaic virus
1auy, 1w39 – VCP – turnip yellow mosaic virus
3zxa - tcvVCP – turnip crinkle virus
3zx8, 3zx9 – tcvVCP – Cryo EM
1f2n - VCP – rice yellow mosaic virus
1a34, 2tmv, 1ei7 – tmvVCP + RNA]] - satellite tobacco mosaic virus
3j06 - tmvVCP + RNA – Cryo EM
2om3, 2xea – tmvVCP – Cryo EM
3kml – tmvVCP (mutant)
2buk - VCP]] - satellite tobacco necrosis virus
1a6c - VCP]] - tobacco ringspot virus
1e57 – VCP – Physalis mottle virus
2izw - VCP – ryegrass mottle virus
1opo - VCP – carnation mottle virus
1ny7, 1cwp – VCP – cowpea mosaic virus
1za7 - VCP (mutant) – cowpea chlorotic mottle virus
1pgl, 1pgw – VCP + RNA – bean pod mottle virus
2tbv – VCP – tomato bushy stunt virus
1smv – VCP – sesbania mosaic virus
1stm – VCP - satellite panicum mosaic virus
4sbv – VCP – southern bean mosaic virus
1m1c – VCP – yeast L-A virus
1laj – VCP + RNA – tomato aspermy virus
1uf2 – VCP + proteins – rice dwarf virus
3iym – VCP – Penicillium stoloniferum virus – Cryo EM

VCP by fiber diffraction

1cgm – VCP – cucumber green mottle virus

1rmv - VCP + RNA – fibgrass mosaic virus
1pfi, 2ifm – VCP – Pf1 virus
1vtm - VCP - satellite tobacco mosaic virus

VCP of various viruses

2mev, 1mec – VCP – mengo virus

2snv, 2snw, 1svp, 1kxa, 1wyk – svVCP – sindbis virus
1svp, 1kxb, 1kxc, 1kxd, 1kxe, 1kxf – svVCP (mutant) 1ld4, 3j0f – svVCP + envelope proteins – Cryo EM
1bvp – VCP – bluetongue virus VP7
1nov – VCP – Nodamura virus
1mvm, 1z1c – mvVCP + DNA – minute virus
2xgk – mvVCP Vp2 (mutant)
1bbt, 1fod, 1fmd, 1qgc – fmdvVCP – foot and mouth disease virus
2wv4, 2wv5 – fmdvVCP Vp1 + picornain
1fpv, 1c8e, 1c8f, 1c8g – VCP – feline panleukopenia virus
1c8d, 1c8h - VCP – canine panleukopenia virus
2bbv – VCP + RNA – black beetle virus
1pov – VCP – poliovirus
1sva – svVCP – simian virus 40
3bwq, 3bwr – svVCP Vp1 1sid, 1sie, 1vpn, 1vps, 1cn3 – VCP – murine polyomavirus
3s7v - pvVCP Vp1 – polyomavirus
3s7x - pvVCP Vp1 (mutant)
1vcp, 1vcq – VCP – semliki forest virus
2yew - VCP + envelope glycoprotein – Barmah forest virus - Cryo EM
2eia, 1eia – VCP – equine infectious anemia virus
1dnv – VCP – Galleria mellonella densovirus
1ep5, 1ep6 – eevVCP C terminal – equine encephalitis virus
3j0c - eevVCP C terminal + envelope glycoprotein – Cryo EM
3ve6 – eevVCP NLS + importin
1qrj – HtlvVCP – HumanT-cell lymphotrophic virus – NMR
1g03 - HtlvVCP N terminal]] - NMR
1dzl – hpvVCP L1 (mutant) – Human papillomavirus
3iyj - VCP L1 – bovine papillomavirus – Cryo EM
2r5h, 2r5i, 2r5j, 2r5k - hpvVCP L1
[[1f8v – VCP + RNA – pariacoto virus
2r18, [[2z7j – VCP Vp3 – birnavirus
2vf1 – VCP – rabbit picobirnavirus
1jew – VCP + receptor – coxsackievvirus – Cryo EM
1fn9 – VCP sigma 3 – reovirus
3iyl – VCP Vp4+Vp1+Vp3 – grass carp virus – Cryo EM
1lp3, 2g8g, 2qa0, 3ra2, 3ra4, 3ra8, 3ra9, 3raa, 3ng9 – aavVCP – adeno-associated virus
3kic, 3kie, 1vu0, 1vu1, 3shm, 3tsx, 3ux1 – aavVCP Vp1
3j1s - aavVCP Vp1 + antibody
2gh8 – VCP – San Miguel sea lion virus
1j5q, 1m3y – PbcvVCP – Parmecium bursaria chlorella virus
1m4x – PbcvVCP – Cryo EM
1no7 – VCP Vp5 – Human herpes simplex virus
1ohf – VCP – Nudaurelia capensis omega virus
1mqt – VCP – swine vesicular disease virus
2p5p – VCP domain III – West Nile virus
3cnf – VCP Vp1+Vp3 – polyhedrosis virus – Cryo EM
2v4x – VCP N terminal – sheep retrovirus
3fbm – VCP Vp2 – avian infectious bursal disease virus
2qqp – VCP + RNA – Providence virus
2kgf – mpmvVCP N-terminal – Mason-Pfizer monkey virus
4ard – mpmvVCP P27 – Cryo EM
3ide – VCP Vp2 – infectious pancreatic necrosis virus
3lob, 4fte, 4fts – fhvVCP (mutant) + RNA – flock house virus
4fsj, 4ftb - fhvVCP + RNA
3nap – VCP – triatoma virus
2xgu, 2xgv – relvVCP N terminal – rabbit endogenous lentivirus
3zue – VCP Vp60]] - rabbit hemorrhagic disease virus – Cryo EM
2xgy – relvVCP N terminal + cyclophilin
3r0r – VCP – pig circovirus
3izx – bmcvVCP Vp3 + structural protein 5 – Bombyx mori cypovirus
– Cryo EM
3j17 - bmcvVCP Vp3 Vp5
3vbf, 3vbh, 3vbo, 3vbr, 3vbs, 3vbu – VCP – human enterovirus
3s6p – VCP – Helicoverpa armigera stunt virus


Structure of HIV-I coat protein hexamer (PDB entry 3gv2)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman