Pentamer structure of Major Capsid Protein L1 of Human Papilloma Virus type 16Pentamer structure of Major Capsid Protein L1 of Human Papilloma Virus type 16
Structural highlights
2r5h is a 15 chain structure with sequence from Human papillomavirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
A0A1U9YFU1_9PAPI Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
