Stromal Derived Factor 1: Difference between revisions
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[[Image:2kec.jpg|left|thumb|300px|NMR Structure of the Stromal | [[Image:2kec.jpg|left|thumb|300px|NMR Structure of the Stromal cell-derived factor 1α, [[2kec]]]] | ||
{{STRUCTURE_1qg7|right| PDB=1qg7 | SCENE= |CAPTION=Stromal | {{STRUCTURE_1qg7|right| PDB=1qg7 | SCENE= |CAPTION=Stromal cell-derived factor 1α dimer complex with sulfate, [[1qg7]] }} | ||
[[Stromal Derived Factor 1]] (SDF-1α) or CXCL12 is a small cytokine from the chemokine family. It is natural ligand of [[CXC chemokine receptor type 4|CXCR4]] It has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis. The images on the left and right correspond to one representative SDF-1α structure, ''i.e.'' the human SDF-1α ([[2kec]]). | [[Stromal Derived Factor 1]] (SDF-1α) or CXCL12 is a small cytokine from the chemokine family. It is natural ligand of [[CXC chemokine receptor type 4|CXCR4]] It has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis. The images on the left and right correspond to one representative SDF-1α structure, ''i.e.'' the human SDF-1α ([[2kec]]). | ||
Revision as of 13:49, 15 November 2012
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| Stromal cell-derived factor 1α dimer complex with sulfate, 1qg7 | |||||||||
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| Ligands: | |||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Stromal Derived Factor 1 (SDF-1α) or CXCL12 is a small cytokine from the chemokine family. It is natural ligand of CXCR4 It has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis. The images on the left and right correspond to one representative SDF-1α structure, i.e. the human SDF-1α (2kec).
3D Structures of Stromal Derived Factor 13D Structures of Stromal Derived Factor 1
Updated December 2011
2kec, 2ked, 2kee, 2sdf, 1sdf - hSDF1α – NMR - human
1qg7, 3hp3 - hSDF1α
2k0l, 2k01 – hSDF1α (mutant) – NMR
1a15 - hSDF1α (mutant)
2nwg - hSDF1α+heparin
2j7z - hSDF1α residues 22-89
2k03, 2k04, 2k05 - hSDF1α (mutant)+ hCXCR4 N-terminal (mutant)