Lactoperoxidase: Difference between revisions
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{{STRUCTURE_2ips| PDB=2ips | SIZE=400| SCENE= |right|CAPTION=Heme containing bovine lactoperoxidase complex with | {{STRUCTURE_2ips| PDB=2ips | SIZE=400| SCENE= |right|CAPTION=Heme containing glycosylated bovine lactoperoxidase complex with carbonate, thiocyanate, calcium (green) and iodide (purple) ions [[2ips]] }} | ||
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Revision as of 14:28, 5 November 2012
Lactoperoxidase (LPO) catalyzes the oxidation of thiocyanate, bromide and iodide using hydrogen peroxide. The short-lived oxidized intermediates of the reaction serve as potent bactericidal agents. LPO is used as an antimicrobial agent in milk and its products, in cosmetics, toothpaste and ophthalmic solutions. LPO is the second most abundant enzyme in milk. Heme is the cofactor of LPO. LPO contains a strongly-chelated calcium ion.
3D structures of lactoperoxidase3D structures of lactoperoxidase
Lactoperoxidase binary complex
2pt3 - bPLO + phosphate - bovine
2r5l – gLPO + I – goat
3nak – gLPO + formate
Lactoperoxidase ternary complex
2gj1 – bLPO + carbonate + nitrate
2ips, 3eri, 3gc1 – bLPO + SCN + I
2qrb – bLPO + SCN + Cl
3bxi – bLPO + SCN + nitrate
2pum – bPLO + catechol + I
2gj1 – bLPO + carbonate + nitrate
3krq – bLPO + amino-triazole + I
2z5z – wbPLO + F + I – water buffalo
2o86 – wbPLO + nitrate + I
3erh - wbLPO + SCN + I
2ojv – gPLO + CN + I
3n8f - gLPO + SCN + nitrate
3niu – gLPO + diethylene glycol + phosphate
3rke - gPLO + inhibitor + I
2ikc – sLPO + carbonate + formate – sheep
Lactoperoxidase quaternary complex
3gcj, 2qpk - bPLO + salicylhydroxamic acid + SCN + I
3gck - bPLO + benzylhydroxamic acid + SCN + I
3uba - bPLO + hydroxycinnamic acid + SCN + I
3gcl, 2qqt - bPLO + aspirin + SCN + I
3i6n - bPLO + isoniazid + SCN + I
3nyh - bPLO + Br + Cl + SCN + I
3ogw - bPLO + indomethacin + SCN + I
3py4 - bPLO + paracetamol + SCN + I
3q9k - bPLO + phenyliso-SCN + SCN + I
3ql6 - bPLO + nitro-phenoxymethanesulfonanilide+ SCN + I
3s4f - bPLO + pyridine derivative + SCN + I
3r4x, 3tuw - bPLO + pyrazine derivative + SCN + I
3r5o - bPLO + methoxyphenol + SCN + I
3tgy - bPLO + ascorbate + SCN + I
3v6q - bPLO + CO + SCN + I
2gjm - wbPLO + carbonate + SCN + I
3faq – wbLPO + CN + SCN + I
3fnl - wbPLO + salicylhydroxamic acid + SCN + I
2e9e – gPLO + nitrate + carbonate + SCN + CN
2efb – gPLO + phosphate + carbonate + SCN + CN
3qf1 - gPLO + piperazine + SCN + I
2eha – gPLO + formate + carbonate + SCN
3r55 - gPLO + pyrazine derivative + SCN + I
3sxv - gPLO + amitrole + SCN + I
3r5q - sPLO +tetrahydrofuran + SCN + I