Serpin: Difference between revisions

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<StructureSection load='3ndd' size='400' side='right' caption='Structure of cleaved human serpin A1 (PDB entry [[3ndd]])' scene=''>
<StructureSection load='3ndd' size='400' side='right' caption='Structure of cleaved human serpin A1.  Residues 46-382 (grey), residues 383-418 (green). (PDB entry [[3ndd]])' scene=''>


'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.  Ser E1 is antithrombin.  Ser C1 is  antithrombin .  Ser A5 is protein C inhibitor.  Ser A6 is a cortisol-binding globulin.  Ser A8 is angiotensinogen.    Ser A7 is a thyroxine-binding globulin.  Ser B3 is squamos cell carcinoma antigen 1.  Ser I1 is neuroserpin.  Ser A10 is protein Z-related protease inhibitor.  Ser A1 is alpha-1 antitrypsin.  Ser E1 is plasminogen activator inhibitor 1.   
'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.  Ser E1 is antithrombin.  Ser C1 is  antithrombin .  Ser A5 is protein C inhibitor.  Ser A6 is a cortisol-binding globulin.  Ser A8 is angiotensinogen.    Ser A7 is a thyroxine-binding globulin.  Ser B3 is squamos cell carcinoma antigen 1.  Ser I1 is neuroserpin.  Ser A10 is protein Z-related protease inhibitor.  Ser A1 is alpha-1 antitrypsin.  Ser E1 is plasminogen activator inhibitor 1.   

Revision as of 15:11, 24 October 2012


Serpin or serine protease inhibitor (Ser) are protease inhibitors. Ser E1 is antithrombin. Ser C1 is antithrombin . Ser A5 is protein C inhibitor. Ser A6 is a cortisol-binding globulin. Ser A8 is angiotensinogen. Ser A7 is a thyroxine-binding globulin. Ser B3 is squamos cell carcinoma antigen 1. Ser I1 is neuroserpin. Ser A10 is protein Z-related protease inhibitor. Ser A1 is alpha-1 antitrypsin. Ser E1 is plasminogen activator inhibitor 1.

3D structures of serpin

Ser

1mtp, 1sng – Ser – Thermobifida fusca

Ser A1

Alpha-1-antitrypsin

Ser A5

2ol2 – hSer-A5

3dy0 – hSer-A5 + heparin

Ser A6

Corticosteroid-binding globulin

Ser A7

2riv – hSer-A7

2riw – hSer-A7 + thyroxine
2xn3 – hSer-A7 + mefenamic acid
2xn5 – hSer-A7 + furosemide
2xn6, 2xn7 – hSer-A7 + thyroxine-fluoresein

Ser A8

2jp8 – hSer-A8 – NMR

2wxw – hSer-A8
2x0b – hSer-A8 + renin
2wxx, 2wxy, 2wy0 – Ser-A8 – mouse
2wxz, 2wy1 – rSer-A8

Ser A10

3h5c, 3f1s – hSer-A10 + vitamin K-dependent protein Z

Ser B3

2zv6 – hSer-B3

Ser C1

Antithrombin

Ser E1

Plasminogen activator inhibitor

Ser E2

4dy0 – hSer-E2 + heparin

Ser-I1

3fgq, 2f02, 3f5n – hSer-I1

Ser K

1sek – ThSer-K – Tobacco hornworm

Ser 1

1k9o – ThSer-1 (mutant) + trypsin II

3le2 – Ser-1 – Arabidopsis thaliana

Ser 2

1m93 – Ser-2 – Cowpox virus

3nda – Ser-2 – Sheep tick
3pzf – Ser-2 – malaria mosquito

Maspin

1xqg, 1xqj, 1wz9, 1xu8 - hMapsin





Structure of cleaved human serpin A1. Residues 46-382 (grey), residues 383-418 (green). (PDB entry 3ndd)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky