1m7k: Difference between revisions
New page: left|200px<br /> <applet load="1m7k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m7k" /> '''Solution Structure of the SODD BAG Domain''... |
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'''Solution Structure of the SODD BAG Domain'''<br /> | '''Solution Structure of the SODD BAG Domain'''<br /> | ||
==Overview== | ==Overview== | ||
The solution structure of an N-terminally extended construct of the SODD | The solution structure of an N-terminally extended construct of the SODD BAG domain was determined by nuclear magnetic resonance spectroscopy. A homology model of the SODD-BAG/HSP70 complex reveals additional possible interactions that are specific for the SODD subfamily of BAG domains while the overall geometry of the complex remains the same. Relaxation rate measurements show that amino acids N358-S375 of SODD which were previously assigned to its BAG domain are not structured in our construct. The SODD BAG domain is thus indeed smaller than the homologous domain in Bag1 defining a new subfamily of BAG domains. | ||
==About this Structure== | ==About this Structure== | ||
1M7K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1M7K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7K OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: three helix bundle]] | [[Category: three helix bundle]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:52:21 2008'' | ||
Revision as of 14:52, 21 February 2008
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Solution Structure of the SODD BAG Domain
OverviewOverview
The solution structure of an N-terminally extended construct of the SODD BAG domain was determined by nuclear magnetic resonance spectroscopy. A homology model of the SODD-BAG/HSP70 complex reveals additional possible interactions that are specific for the SODD subfamily of BAG domains while the overall geometry of the complex remains the same. Relaxation rate measurements show that amino acids N358-S375 of SODD which were previously assigned to its BAG domain are not structured in our construct. The SODD BAG domain is thus indeed smaller than the homologous domain in Bag1 defining a new subfamily of BAG domains.
About this StructureAbout this Structure
1M7K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The solution structure of the SODD BAG domain reveals additional electrostatic interactions in the HSP70 complexes of SODD subfamily BAG domains., Brockmann C, Leitner D, Labudde D, Diehl A, Sievert V, Bussow K, Kuhne R, Oschkinat H, FEBS Lett. 2004 Jan 30;558(1-3):101-6. PMID:14759524
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