Integrin

<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrein CD11a I domain complex with Mg+2 (PDB entry 1zoo)' scene=>

Integrins (IG) are receptors which mediate the attachment between cells or to extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain alpha and beta chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain.

3D structures of integrin3D structures of integrin

IG CR3IG CR3

1ido – hIG I domain + Mg – human
1jlm - hIG I domain + Mn

IG CD11aIG CD11a

1lfa - hIG I domain + Mn
1zon - hIG I domain
1zoo, 1zop, 3f74 - hIG I domain + Mg
1mq9 - hIG I domain (mutant) + Mn
1mjn - hIG I domain (mutant) + Mg
1mqa - hIG I domain (mutant)
2k8o – hIG cytoplasmic domain (mutant) – NMR

IG CD11a complexes

1cqp - hIG I domain + lovastatin + Mg
1mq8, 3bn3, 3tcx - hIG I domain (mutant) + intracellular adhesion molecule + Mg
1t0p - hIG I domain + intracellular adhesion molecule-3 + Mg
1rd4, 2ica, 3bqm, 3bqn, 3e2m - hIG I domain + inhibitor
2o7n, 3m6f - hIG I domain + antagonist
1xdd, 1xdg, 1xuo - hIG I domain + inhibitor + Mg
3f78 - hIG I domain + anesthetic + Mg
3eoa, 3eob - hIG I domain + antibody
3hi6 - hIG I domain (mutant) + antibody + Mn

IG CD11bIG CD11b

1bho - hIG I domain + Mg
1bhq - hIG I domain + Cd
1m1u - hIG I domain (mutant) + Ca
1n9z - hIG I domain (mutant) + Mg
1idn, 1na5 - hIG I domain
1mf7 - hIG I domain (mutant)

IG CD11cIG CD11c

1n3y - hIG I domain (mutant)

IG α-1IG α-1

1ck4 - rIG I domain – rat
4a0q - hIG I domain (mutant) + Mg
2l8s - hIG transmembrane domain – NMR
1mhp - rIG I domain (mutant) + antibody + Mn

IG α-2IG α-2

1dzi - hIG I domain + collagen peptide
1v7p - hIG I domain (mutant) + EMS16 + Mn

IG α-2bIG α-2b

2k1a - hIG transmembrane domain – NMR

IG α-MIG α-M

2lke, [[2lkj – hIG cytoplasmic domain – NMR

IG α-XIG α-X

2luv – hIG cytoplasmic domain – NMR

IG α-1 β-1IG α-1 β-1

1qc5, 1qcy - hIG I domain (mutant) + Mg
1pt6 - hIG I domain + Mg

IG α-2 βIG α-2 β

1aox - hIG I domain (mutant) + Mg
1s4w - hIG cytoplasmic domain]] - NMR

IG α-2b β-3IG α-2b β-3

1kup, 1kuz – hIG proximal domain – NMR
1m8o - hIG cytoplasmic domain – NMR
2k9j, 2knc - hIG transmembrane domain – NMR
1tye, 3fcu – hIG + Mg
3fc3 – hIG (mutant) + Mg
2vc2, 2vdk, 2vdl, 3nid, 3nif, 3nig – hIG headpiece + antibody + Mg
2vdm, 2vdn, 3t3m, 3t3p – hIG headpiece + antibody + antagonist + Mg
2vdo, 2vdp, 2vdq, 2vdr – hIG headpiece + antibody + fibrinogen peptide + Mg

IG α-4 β-7IG α-4 β-7

3v4p - hIG headpiece (mutant) + antibody + Mg
3v4v - hIG headpiece (mutant) + antibody + inhibitor + Mg

IG α-5 β-1IG α-5 β-1

3vi3 - hIG headpiece + antibody + Mg
3vi4 - hIG headpiece + antibody + peptide + Mg

IG α-5 β-3IG α-5 β-3

3ije – hIG + Ca
1m1x - hIG extracellular domain + Mn
1u8c – hIG psi domain + Ca
1jv2 - hIG I domain + platelet membrane glycoprotein IIIA + Ca
1l5g - hIG I domain + tripeptide + Mn

IG α-X β-2IG α-X β-2

3k6s, 3k71, 3k72 – hIG + Mg

IG β-2IG β-2

2p26, 2p28 – hIG phe2 + phe3 domains

IG β-3IG β-3

1s4x, 2kv9, 2ljd, 2lje, 2ljf – hIG cytoplasmic domain – NMR
2rmz, 2rn0 – hIG transmembrane domain – NMR
2l91 - hIG transmembrane domain (mutant) – NMR

IG β-4IG β-4

2f7q, 3f7r - hIG fibronectin type III domain
2yrz – hIG fibronectin type III domain – NMR
3f7p - hIG fibronectin type III domain + plectin-1 + Ca
3fq4, 3fso, 3h6a – hIG Calx-β domain