1ef5: Difference between revisions
New page: left|200px<br /><applet load="1ef5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ef5" /> '''SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN... |
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[[Image:1ef5.jpg|left|200px]]<br /><applet load="1ef5" size=" | [[Image:1ef5.jpg|left|200px]]<br /><applet load="1ef5" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL'''<br /> | '''SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL'''<br /> | ||
==Overview== | ==Overview== | ||
The RGL protein, a homolog of the Ral GDP dissociation stimulator | The RGL protein, a homolog of the Ral GDP dissociation stimulator (RalGDS), has been identified as a downstream effector of Ras. In the present study, the solution structure of the Ras-binding domain of RGL (RGL-RBD) was determined by NMR spectroscopy. The overall fold of RGL-RBD consists of a five-stranded beta-sheet and two alpha-helices, which is the same topology as that of RalGDS-RBD. The backbone chemical shift perturbation of RGL-RBD upon interaction with the GTP analog-bound Ras was also examined. The solution structure of RGL-RBD, especially around some of the Ras-interacting residues, is appreciably different from that of RalGDS-RBD. | ||
==About this Structure== | ==About this Structure== | ||
1EF5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | 1EF5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EF5 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Kigawa, T.]] | [[Category: Kigawa, T.]] | ||
[[Category: Kikuchi, A.]] | [[Category: Kikuchi, A.]] | ||
[[Category: RSGI, RIKEN | [[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]] | ||
[[Category: Shirouzu, M.]] | [[Category: Shirouzu, M.]] | ||
[[Category: Yokoyama, S.]] | [[Category: Yokoyama, S.]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:27:04 2008'' | ||
