2hz4: Difference between revisions

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{{Seed}}
[[Image:2hz4.png|left|200px]]
[[Image:2hz4.png|left|200px]]


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{{STRUCTURE_2hz4|  PDB=2hz4  |  SCENE=  }}  
{{STRUCTURE_2hz4|  PDB=2hz4  |  SCENE=  }}  


===Abl kinase domain unligated and in complex with tetrahydrostaurosporine===
===Abl kinase domain unligated and in complex with tetrahydrostaurosporine===


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{{ABSTRACT_PUBMED_17164530}}


==Disease==
==About this Structure==
Known disease associated with this structure: Leukemia, Philadelphia chromosome-positive, resistant to imatinib OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=189980 189980]]
[[2hz4]] is a 3 chain structure of [[Proto-oncogene tyrosine-protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HZ4 OCA].


==About this Structure==
==See Also==
2HZ4 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HZ4 OCA].
*[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:17164530</ref><references group="xtra"/>
<ref group="xtra">PMID:017164530</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
Line 34: Line 22:
[[Category: Liebetanz, J.]]
[[Category: Liebetanz, J.]]
[[Category: Manley, P.]]
[[Category: Manley, P.]]
[[Category: Transferase]]
[[Category: Tyrosine kinase]]
[[Category: Tyrosine kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:03:29 2009''

Revision as of 17:11, 25 July 2012

File:2hz4.png

Template:STRUCTURE 2hz4

Abl kinase domain unligated and in complex with tetrahydrostaurosporineAbl kinase domain unligated and in complex with tetrahydrostaurosporine

Template:ABSTRACT PUBMED 17164530

About this StructureAbout this Structure

2hz4 is a 3 chain structure of Proto-oncogene tyrosine-protein kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. ↑ Cowan-Jacob SW, Fendrich G, Floersheimer A, Furet P, Liebetanz J, Rummel G, Rheinberger P, Centeleghe M, Fabbro D, Manley PW. Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia. Acta Crystallogr D Biol Crystallogr. 2007 Jan;63(Pt 1):80-93. Epub 2006, Dec 13. PMID:17164530 doi:http://dx.doi.org/10.1107/S0907444906047287

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