1odh: Difference between revisions
New page: left|200px<br /> <applet load="1odh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1odh, resolution 2.85Å" /> '''STRUCTURE OF THE GC... |
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==About this Structure== | ==About this Structure== | ||
1ODH is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ODH OCA]]. | 1ODH is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ODH OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:36:04 2007'' | ||
Revision as of 14:31, 30 October 2007
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STRUCTURE OF THE GCM DOMAIN BOUND TO DNA
OverviewOverview
Glia cell missing (GCM) transcription factors form a small family of, transcriptional regulators in metazoans. The prototypical Drosophila GCM, protein directs the differentiation of neuron precursor cells into glia, cells, whereas mammalian GCM proteins are involved in placenta and, parathyroid development. GCM proteins share a highly conserved 150 amino, acid residue region responsible for DNA binding, known as the GCM domain., Here we present the crystal structure of the GCM domain from murine GCMa, bound to its octameric DNA target site at 2.85 A resolution. The GCM, domain exhibits a novel fold consisting of two domains tethered together, by one of two structural Zn ions. We observe the novel use of a beta-sheet, in DNA recognition, whereby a five- stranded beta-sheet protrudes into ... [(full description)]
About this StructureAbout this Structure
1ODH is a [Protein complex] structure of sequences from [Mus musculus] with ZN as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition., Cohen SX, Moulin M, Hashemolhosseini S, Kilian K, Wegner M, Muller CW, EMBO J. 2003 Apr 15;22(8):1835-45. PMID:12682016
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