Dethiobiotin synthetase: Difference between revisions
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[[1dad]] – EcDTBS + ADP<BR /> | [[1dad]] – EcDTBS + ADP<BR /> | ||
[[1dae]] - EcDTBS + nonanedioate derivative<br /> | [[1dae]] - EcDTBS + nonanedioate derivative<br /> | ||
[[ | [[3fmi]] – MtDTBS + aminopelargonic acid<br /> | ||
[[1dai]] - EcDTBS + DAN | [[1dai]] - EcDTBS + DAN | ||
Revision as of 10:24, 8 May 2012
Dethiobiotin synthetase (DTBS) catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin, ADP and phosphate.
3D dethiobiotin synthetase3D dethiobiotin synthetase
1dbs, 1dts, 1byi]] – EcDTBS – Escherichia coli
2qmo – HpDTBS – Helicobacter pylori
3fgn – MtDTBS – Mycobacterium tuberculosis
3of5 – DTBS – Francicella tularensis
DTBS binary complex
3fmf – MtDTBS + DAN
1dad – EcDTBS + ADP
1dae - EcDTBS + nonanedioate derivative
3fmi – MtDTBS + aminopelargonic acid
1dai - EcDTBS + DAN
DTBS ternary complex
3qxc - HpDTBS + Mg + ATP
1daf - EcDTBS + DAN + ADP
1dag - EcDTBS + DAN + ATP derivative
3qxj - HpDTBS + Mg + ATP
3qxs - HpDTBS + Mg + phosphoaminophosphonic acid
DTBS quaternary complex
1dah - EcDTBS + DAN + Mn + ATP<BR / derivative
1bs1 - EcDTBS + DAN + Mg + ADP
1a82 - EcDTBS + DAN + Mg + ATP
3fpa - MtDTBS + DAN + Mg + phosphate
3mle - HpDTBS + Mg + phosphate + ADP
3qy0 - HpDTBS + Mg + phosphate + GDP
DTBS higher complexes
1dam - EcDTBS + DAN + Mg + phosphate + ADP
1dak - EcDTBS + DAN + mixed anhydride + Mg + phosphate + ADP
3qxh - HpDTBS + aminooctanoic acid + Mg + phosphate + ADP
3qxx - HpDTBS + aminooctanoic acid + Mg + phosphate + GTP