Sandbox Reserved 478: Difference between revisions
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'''Matrix Metalloproteinase 1'''(MMP1) also known as Interstitial collagenase is a zinc-dependent protease that degrades extracellular matrix proteins.<ref name="Nagase">Nagase, H., Barrett, A. J., Woessner, J. F., Jr. Nomenclature and glossary of the matrix metalloproteinases. Matrix Suppl. 1: 421-424, 1992.</ref> [http://en.wikipedia.org/wiki/Collagenase Collagenases] are enzymes, which cleave bonds in collagen. MMP1 belongs to the | '''Matrix Metalloproteinase 1'''(MMP1) also known as Interstitial collagenase is a zinc-dependent protease that degrades extracellular matrix proteins.<ref name="Nagase">Nagase, H., Barrett, A. J., Woessner, J. F., Jr. Nomenclature and glossary of the matrix metalloproteinases. Matrix Suppl. 1: 421-424, 1992.</ref> [http://en.wikipedia.org/wiki/Collagenase Collagenases] are enzymes, which cleave bonds in collagen. MMP1 belongs to the [[Matrix_Metalloproteinase]] (MMP) family, which are involved in the regulation of cell-matrix composition by the breakdown of the extracellular matrix in normal physiological processes. These physiological processes many include disease activities such as arthritis and metastasis as well as normal human reproduction and embryonic development.<ref name="Visse">Visse, Robert, and Hideaki Nagase. "Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases." Circulation Research 92 (2003): 827-39.</ref> | ||
{{STRUCTURE_2clt| PDB=2clt | SCENE= }} | {{STRUCTURE_2clt| PDB=2clt | SCENE= }} | ||
==Structure== | ==Structure== | ||