Sandbox Reserved 492: Difference between revisions
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While measures of treating someone with CX intoxication generally involves carefully replenishing electrolytes and other vital fluids there have been plenty of tests conducted that show that the toxin can be directly inhibited on the molecular level as well. The catalytic subunit of the CX protein has shown to bind, with high affinity a molecule known as PJ34- as well as other structurally conserved, fused-hydrocarbon ring inhibitors. Essentially, the PJ34 replaces what would target protein in the epithelial cell of a human host and prevent the ill effects of intoxication...in theory. | While measures of treating someone with CX intoxication generally involves carefully replenishing electrolytes and other vital fluids there have been plenty of tests conducted that show that the toxin can be directly inhibited on the molecular level as well. The catalytic subunit of the CX protein has shown to bind, with high affinity a molecule known as PJ34- as well as other structurally conserved, fused-hydrocarbon ring inhibitors. Essentially, the PJ34 replaces what would target protein in the epithelial cell of a human host and prevent the ill effects of intoxication...in theory. | ||
<Structure load='2q6m' size='425 color='black' frame='true' align='middle' caption='X-Ray Diffraction image at 2.1Å of catalytic fragment with PJ34 inhibitor bound.' /> | <Structure load='2q6m' size='425' color='black' frame='true' align='middle' caption='X-Ray Diffraction image at 2.1Å of catalytic fragment with PJ34 inhibitor bound.' /> | ||
An aspiration for research being done on the Cholera Toxin coincides with a current "hot topic" within the science community and society around the world: '''Stem Cell Research.''' There have been some recent findings indicating that the protein may be capable of interacting - regulation on the genetic level - some key factors in Neural Stem Cell '''(NSC)''' regeneration and differentiation. Known as Tie2, a membrane receptor, and Hes3 a transcription factor, these two indicators have been shown to directly interact with the Cholix Toxin. Moreover, there are even some implications that the protein, when combined with specific medium, boosted Stem Cell culture growth.[5] Thus, we see that apart from its potential to cause human illness, CX also poses the potential to offer a solution to cancer and other related diseases. | An aspiration for research being done on the Cholera Toxin coincides with a current "hot topic" within the science community and society around the world: '''Stem Cell Research.''' There have been some recent findings indicating that the protein may be capable of interacting - regulation on the genetic level - some key factors in Neural Stem Cell '''(NSC)''' regeneration and differentiation. Known as Tie2, a membrane receptor, and Hes3 a transcription factor, these two indicators have been shown to directly interact with the Cholix Toxin. Moreover, there are even some implications that the protein, when combined with specific medium, boosted Stem Cell culture growth.[5] Thus, we see that apart from its potential to cause human illness, CX also poses the potential to offer a solution to cancer and other related diseases. | ||