Sandbox Reserved 478: Difference between revisions
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The Structure of MMP-1 and all other members of the Metalloproteinase family for that matter are formed from three domains. The structure comprises of the N-terminal catalytic domain, the linker region and the C-terminal hemopexin domain. The structure of human MMP-1 was determined with X-Ray Crystallography at a resolution of 2.67A to have two monomers (chains A and B). The catalytic domain of one monomer contacts the hemopexin domain of the other monomer. An interesting observation that has been noted is that the contact site used by the two monomers in the asymmetric unit to form the dimer is not the same as the dimerization site observed in the structure of the MMP-9 hemopexin domain. This difference shows that not all members of the Matrix Metalloproteinase family behave the same in their dimerization processes. | The Structure of MMP-1 and all other members of the Metalloproteinase family for that matter are formed from three domains. The structure comprises of the N-terminal catalytic domain, the linker region and the C-terminal hemopexin domain. The structure of human MMP-1 was determined with X-Ray Crystallography at a resolution of 2.67A to have two monomers (chains A and B). The catalytic domain of one monomer contacts the hemopexin domain of the other monomer. An interesting observation that has been noted is that the contact site used by the two monomers in the asymmetric unit to form the dimer is not the same as the dimerization site observed in the structure of the MMP-9 hemopexin domain. This difference shows that not all members of the Matrix Metalloproteinase family behave the same in their dimerization processes. | ||
===Domain=== | ===Catalytic Domain=== | ||
klklm | klklm | ||
lkm | lkm | ||
lkm | lkm | ||
===Linker Region=== | |||
asdflkafalkfna;lkdf | |||
adfa | |||
fa | |||
fa | |||
===Hemopexin-like Domain=== | |||
adlskflam | |||
adfafdaf | |||
afa | |||
f | |||
==Mechanism of Action== | ==Mechanism of Action== | ||
sdfglkmsdfsd | sdfglkmsdfsd | ||