Transferrin receptor: Difference between revisions
No edit summary |
No edit summary |
||
| Line 6: | Line 6: | ||
to a Jmol applet. Check out the other buttons as well! | to a Jmol applet. Check out the other buttons as well! | ||
--> | --> | ||
'''Transferrin receptor''' (TfR) imports iron into the cell by receptor-mediated endocytosis of transferrin-iron complex. TfR is regulated by intracellular iron concentration. The amount of TfR expressed on the cell is proportional to the cell’s need for iron. The TfR has selective affinity for diferric-transferrin. The TfR-transferrin complex is internalized by the cell and iron is released to the cytosol. The TfR-apotransferrin complex returns to the extracellular surface where the apotransferrin dissociates and is replaced by diferric-transferrin. | '''Transferrin receptor''' (TfR) imports iron into the cell by receptor-mediated endocytosis of [[Transferrin|transferrin]]-iron complex. TfR is regulated by intracellular iron concentration. The amount of TfR expressed on the cell is proportional to the cell’s need for iron. The TfR has selective affinity for diferric-transferrin. The TfR-transferrin complex is internalized by the cell and iron is released to the cytosol. The TfR-apotransferrin complex returns to the extracellular surface where the apotransferrin dissociates and is replaced by diferric-transferrin. | ||
==3D structures of transferrin receptor== | ==3D structures of transferrin receptor== | ||
Revision as of 14:38, 14 March 2012
Transferrin receptor (TfR) imports iron into the cell by receptor-mediated endocytosis of transferrin-iron complex. TfR is regulated by intracellular iron concentration. The amount of TfR expressed on the cell is proportional to the cell’s need for iron. The TfR has selective affinity for diferric-transferrin. The TfR-transferrin complex is internalized by the cell and iron is released to the cytosol. The TfR-apotransferrin complex returns to the extracellular surface where the apotransferrin dissociates and is replaced by diferric-transferrin.
3D structures of transferrin receptor3D structures of transferrin receptor
1cx8 – hTfR ectodomain – human
1de4 - hTfR ectodomain + hemochromatosis protein + β-2-microglobulin
1suv - hTfR ectodomain + transferrin
3s9l, 3s9m, 3s9n - hTfR ectodomain + transferrin N-lobe
2nsu - hTfR ectodomain in dog retrovirus – EM
3kas - hTfR ectodomain + Machupo virus GP1