Thermolysin: Difference between revisions
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[[Image:3dnz.jpg|left|200px|thumb|Crystal Structure of Thermolysin [[3dnz]]]] | [[Image:3dnz.jpg|left|200px|thumb|Crystal Structure of Thermolysin [[3dnz]]]] | ||
{{STRUCTURE_3dnz| PDB=3dnz | SIZE= | {{STRUCTURE_3dnz| PDB=3dnz | SIZE=400| SCENE=Thermolysin/Cv/1 |right|CAPTION=Thermolysin complex with Ca and Zn ions [[3dnz]] }} | ||
[[Thermolysin]] (TML) is a thermostable metalloproteinase enzyme from ''Bacillus thermoproteolyticus''. It catalyzes the hydrolysis of peptide bonds containing hydrophobic residues. The images at the left and at the right correspond to one representative Thermolysin ([[3dnz]]). See [[Metalloproteases]] and [[Matrix metalloproteinase]] for discussion. | [[Thermolysin]] (TML) is a thermostable metalloproteinase enzyme from ''Bacillus thermoproteolyticus''. It catalyzes the hydrolysis of peptide bonds containing hydrophobic residues. The images at the left and at the right correspond to one representative Thermolysin ([[3dnz]]). See [[Metalloproteases]] and [[Matrix metalloproteinase]] for discussion. | ||
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== 3D Structures of Thermolysin == | == 3D Structures of Thermolysin == | ||
''Update | ''Update December 2011'' | ||
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[[3fv4]], [[3fxp]], [[3flf]], [[3fb0]], [[3fcq]], [[3f28]], [[3f2p]] – TML residues 233-548+inhibitor<br /> | [[3fv4]], [[3fxp]], [[3flf]], [[3fb0]], [[3fcq]], [[3f28]], [[3f2p]] – TML residues 233-548+inhibitor<br /> | ||
[[3fwd]], [[3for]], [[1y3g]], [[1zdp]], [[1z9g]], [[1pes]], [[1pe7]], [[1pe8]], [[1os0]], [[1kto]], [[1ks7]], [[1kro]], [[1kr6]], [[1kkk]], [[1kjo]], [[1kjp]], [[1qf0]], [[1qf1]], [[1qf2]], [[1hyt]], [[1thl]], [[6tmn]], [[7tln]], [[4tln]], [[5tln]], [[1pe5]], [[3ms3]], [[3msa]], [[3msf]], [[3msn]], [[3n21]], [[3nn7]] – TML+inhibitor<br /> | [[3fwd]], [[3for]], [[1y3g]], [[1zdp]], [[1z9g]], [[1pes]], [[1pe7]], [[1pe8]], [[1os0]], [[1kto]], [[1ks7]], [[1kro]], [[1kr6]], [[1kkk]], [[1kjo]], [[1kjp]], [[1qf0]], [[1qf1]], [[1qf2]], [[1hyt]], [[1thl]], [[6tmn]], [[7tln]], [[4tln]], [[5tln]], [[1pe5]], [[3ms3]], [[3msa]], [[3msf]], [[3msn]], [[3n21]], [[3nn7]] – TML+inhibitor<br /> | ||
[[3ssb]] – TML + Impi-α | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 12:52, 20 December 2011
Thermolysin (TML) is a thermostable metalloproteinase enzyme from Bacillus thermoproteolyticus. It catalyzes the hydrolysis of peptide bonds containing hydrophobic residues. The images at the left and at the right correspond to one representative Thermolysin (3dnz). See Metalloproteases and Matrix metalloproteinase for discussion.
3D Structures of Thermolysin3D Structures of Thermolysin
Update December 2011
ThermolysinThermolysin
2whz, 3fvp, 3dnz, 3do0, 3do1, 3do2, 2g4z, 2a7g, 1gxw, 1kei, 1l3f, 1tlx, 2tlx, 8tln, 3p7p, 3p7q, 3p7r, 3p7s, 3p7t, 3p7u, 3p7v, 3p7w – TML
3ls7 - TML residues 233-548
1trl - TML residues 255-316 – NMR
3fxs, 3fbo, 3eim, 1lna, 1lnb, 1lnc, 1lnd, 1lne, 1lnf - TML residues 233-548+metal ion replacing Ca
TML+transition state analogTML+transition state analog
1tlp, 1tmn, 2tmn, 4tmn, 5tmn – TML+transition state analog
TML+ amino acidTML+ amino acid
1kl6 – TML+ alanine
TML+ dipeptideTML+ dipeptide
2wi0, 3tmn – TML+ dipeptide
3fgd - TML residues 233-548+dipeptide
TML+inhibitorTML+inhibitor
1fjo, 1fj3, 1fjq, 1fjt, 1fju, 1fjv, 1fjw, 4tli, 5tli, 6tli, 7tli, 8tli, 1tli, 2tli, 3tli – TML soaked in organic solvents
3fv4, 3fxp, 3flf, 3fb0, 3fcq, 3f28, 3f2p – TML residues 233-548+inhibitor
3fwd, 3for, 1y3g, 1zdp, 1z9g, 1pes, 1pe7, 1pe8, 1os0, 1kto, 1ks7, 1kro, 1kr6, 1kkk, 1kjo, 1kjp, 1qf0, 1qf1, 1qf2, 1hyt, 1thl, 6tmn, 7tln, 4tln, 5tln, 1pe5, 3ms3, 3msa, 3msf, 3msn, 3n21, 3nn7 – TML+inhibitor
3ssb – TML + Impi-α